Evidence map›Paper›PMID 38625796›Full record

ArticleCell reports2024

CCR2

Lingxiao Wang, Jiaying Zheng, Shunyi Zhao, Yushan Wan, Meijie Wang, Dale B Bosco, Chia-Yi Kuan, Jason R Richardson, Long-Jun Wu

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Engulfment by brain macrophages in a short-lived vertebrate.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lingxiao WangDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA.
Jiaying ZhengDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA.
Shunyi ZhaoDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA.
Yushan WanDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Meijie WangDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
Dale B BoscoDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Chia-Yi KuanDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Jason R RichardsonDepartment of Environmental Health Science, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.
Long-Jun WuDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: longjun.wu@uth.tmc.edu.
Mayo Clinic · USFlorida International University · USUniversity of Virginia · US

Funding

Microglial Hv1 Proton Channel as a Mediator of Environmentally-Induced Neuroinflammation and NeurodegenerationR01ES033892 · NIEHS · UNIVERSITY OF GEORGIA · PI Jason R Richardson, Long-Jun Wu · 2022 to 2026
$3.4M
How microglia sense and regulate neuronal activity in the adult brainR35NS132326 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Long-Jun Wu · 2023 to 2026
$3.2M
CMRO2 and Uncoupling of Oxidative-Phosphorylation in Experimental HIER01NS125677 · NINDS · UNIVERSITY OF VIRGINIA · PI Song Hu, Chia-Yi Kuan · 2022 to 2026
$2.8M
Neutrophils and Monocytes in Pediatric Ischemic StrokeR01NS125788 · NINDS · UNIVERSITY OF VIRGINIA · PI Chia-Yi Kuan · 2022 to 2026
$2.1M
Monocyte-Derived Microglia in Development and after Neonatal Brain InjuryR21HD109025 · NICHD · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2023 to 2024
$444k
Perivascular Fibroblast-Endothelium Interactions in Hypertension and Cerebral IschemiaR21NS127392 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2022 to 2023
$444k
NICHD NIH HHS R21 HD109025NIEHS NIH HHS R01 ES033892NINDS NIH HHS R01 NS125677NINDS NIH HHS R01 NS125788NINDS NIH HHS R21 NS127392NINDS NIH HHS R35 NS132326
6 · The paper itself

Abstract

Border-associated macrophages (BAMs) are tissue-resident macrophages that reside at the border of the central nervous system (CNS). Since BAMs originate from yolk sac progenitors that do not persist after birth, the means by which this population of cells is maintained is not well understood. Using two-photon microscopy and multiple lineage-tracing strategies, we determine that CCR2

Indexed as

BrainMacrophagesMonocytesReceptors, CCR2AnimalsHomeostasisMiceMice, Inbred C57BLCcr2 protein, mouseReceptors, CCR2BAMborder-associated macrophagesbrain compressionCCR2CP: ImmunologyCP: Neurosciencecsf1LPSmeningitismicrogliamonocyterepopulation

Identifiers

PMID38625796
PMCPMC11105166
OpenAlexW4394824548

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.