Evidence map›Paper›PMID 38626285›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

The Spectrum of GH Excess in Carney Complex and Genotype-phenotype Correlations.

Christina Tatsi, Georgia Pitsava, Fabio R Faucz, Meg Keil, Constantine A Stratakis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Genetics of familial acromegaly and pituitary gigantism.The Journal of clinical endocrinology and metabolism · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Christina TatsiUnit on Hypothalamic and Pituitary Disorders, Eunice Kennedy Shriver National Institute of Child Health, and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2882-4584
Georgia PitsavaUnit on Hypothalamic and Pituitary Disorders, Eunice Kennedy Shriver National Institute of Child Health, and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Fabio R FauczMolecular Genomics Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7959-9842
Meg KeilOffice of the Clinical Director, Eunice Kennedy Shriver National Institute of Child Health, and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Constantine A StratakisUnit on Hypothalamic and Pituitary Disorders, Eunice Kennedy Shriver National Institute of Child Health, and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4058-5520
National Institutes of Health · US

Funding

Evaluation of Hypothalamic and Pituitary DisordersZIAHD009017 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI TATSI, CHRISTINA · 2022 to 2025
$3.8M
Eunice Kennedy Shriver National Institute of Child Health & Human DevelopmentNIH HHS
6 · The paper itself

Abstract

contextCarney complex (CNC) is a familial neoplasia syndrome associated with GH excess (GHE).

objectiveTo describe the frequency of GHE in a large cohort of patients with CNC and to identify genotype-phenotype correlations.

methodsPatients with CNC with at least 1 biochemical evaluation of GH secretion at our center from 1995 to 2021 (n = 140) were included in the study. Diagnosis of GHE was based on levels of IGF-1, GH suppression during oral glucose tolerance test, GH stimulation after thyrotropin administration and overnight GH secretion.

resultsFifty patients (35.7%) had GHE, and 28 subjects (20%) had symptomatic acromegaly, with median age at diagnosis of 25.3 and 26.1 years, respectively. Most of the patients (99.3%) had a PRKAR1A gene defect. There was a higher risk of GHE in patients harboring a variant that led to no expression of the affected allele [hazard risk (HR): 3.06, 95% confidence interval (CI): 1.2-7.8] and for patients harboring the hotspot variant c.491_492delTG (HR: 2.10, 95% CI: 1.1-4.1). Almost half of patients with CNC had an abnormal finding on pituitary imaging. CNC patients with abnormal pituitary imaging had a higher risk of GHE (HR: 2.94, 95% CI: 1.5-5.8), especially when single or multiple adenoma-like lesions were identified. Management of patients with symptomatic acromegaly involved surgical and medical approaches.

conclusionDysregulation of GH secretion is a common finding in CNC. Knowing the clinical spectrum of this disorder and its association with genetic and imaging characteristics of the patient make more likely its prompt diagnosis and better management.

Indexed as

AcromegalyCarney ComplexHuman Growth HormoneAdolescentAdultChildCyclic AMP-Dependent Protein Kinase RIalpha SubunitFemaleGenetic Association StudiesHumansInsulin-Like Growth Factor IMaleMiddle AgedRetrospective StudiesYoung AdultCyclic AMP-Dependent Protein Kinase RIalpha SubunitHuman Growth HormoneInsulin-Like Growth Factor IPRKAR1A protein, humanacromegalyCarney complexgrowth hormonepituitary

Identifiers

PMID38626285
PMCPMC11834726
OpenAlexW4394857252

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.