Metformin × glycemic control

SynthesisScientific reports2024

PPAR agonists as add-on treatment with metformin in management of type 2 diabetes: a systematic review and meta-analysis.

Saif Alnuaimi et al.PubMed ↗Full text ↗Publisher ↗

  • PPAR agonist plus metforminlooks good hereLower fasting blood sugar, lower long-term blood sugar, lower insulin resistance.Randomised, large.

What the trial testedrandomised · 6,058 people · 2024

Randomised vs metformin alone

Lowered fasting blood sugar

−22.1mg/dl−27.2 to −17.0

PPAR agonist plus metformin vs metformin alone

As reported

difference −22.1 mg/dl, 95% CI −27.2 to −17.0 · the paper's word: fasting glucose

Randomised vs metformin alone

Lowered long-term blood sugar

−0.53percentage points−0.67 to −0.38

PPAR agonist plus metformin vs metformin alone

As reported

difference −0.53 %, 95% CI −0.67 to −0.38 · the paper's word: HbA1c

Randomised vs metformin alone

Lowered insulin resistance

−1.26−2.16 to −0.37

PPAR agonist plus metformin vs metformin alone

As reported

difference −1.26, 95% CI −2.16 to −0.37 · the paper's word: HOMA-IR

Not counted

Lowered fasting insulin

−19.8−29.5 to −10.1

PPAR agonist plus metformin vs metformin alone

As reported

difference −19.8, 95% CI −29.5 to −10.1

Who was studied, and how

6,058people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

PPAR agonist plus metformin
metformin alone

Lowered fasting blood sugar−22.1

Lowered long-term blood sugar−0.53

Lowered insulin resistance−1.26

randomised

the abstract, start to end

of fasting glucose [MD = - 22.07 mg/dl (95% CI - 27.17, - 16.97), HbA1c [MD = - 0.53% (95% CI - 0.67, - 0.38)], HOMA-IR [MD = - 1.26 (95% CI - 2.16, - 0.37)], and fasting insulin [MD = - 19.83 pmol/L (95% CI - 29.54,

← favours treatmentfavours comparator →
could be chance
Fasting glucosePPAR agonist plus metformin vs metformin alone
−22.1−27.2 to −17.0
HbA1cPPAR agonist plus metformin vs metformin alone
−0.53−0.67 to −0.38
HOMA-IRPPAR agonist plus metformin vs metformin alone
−1.26−2.16 to −0.37
Fasting insulinPPAR agonist plus metformin vs metformin alone
−19.8−29.5 to −10.1
MetforminGlycemic control
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12 papers cite it

2024
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this papertrialcites it
Full record →Abstract, authors, funding and every citing paper · PMID 38627464