Evidence map›Paper›PMID 38627570›Full record

ArticleScientific reports2024

Distinct alterations in white matter properties and organization related to maternal treatment initiation in neonates exposed to HIV but uninfected.

Ndivhuwo Magondo, Ernesta M Meintjes, Fleur L Warton, Francesca Little, Andre J W van der Kouwe, Barbara Laughton, Marcin Jankiewicz, Martha J Holmes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ndivhuwo MagondoDivision of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, Biomedical Engineering Research Centre, University of Cape Town, Cape Town, South Africa. ndi.magondo@uct.ac.za.
Ernesta M MeintjesDivision of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, Biomedical Engineering Research Centre, University of Cape Town, Cape Town, South Africa. ernesta.meintjes@uct.ac.za.
Fleur L WartonDivision of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, Biomedical Engineering Research Centre, University of Cape Town, Cape Town, South Africa.
Francesca LittleDepartment of Statistical Sciences, University of Cape Town, Cape Town, South Africa.
Andre J W van der KouweDivision of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, Biomedical Engineering Research Centre, University of Cape Town, Cape Town, South Africa.
Barbara LaughtonDepartment of Paediatrics and Child Health and Tygerberg Children's Hospital, Faculty of Medicine and Health Sciences, Family Centre for Research with Ubuntu, Stellenbosch University, Stellenbosch, South Africa.
Marcin JankiewiczDivision of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, Biomedical Engineering Research Centre, University of Cape Town, Cape Town, South Africa.
Martha J HolmesDivision of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, Biomedical Engineering Research Centre, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZASimon Fraser University · CAAthinoula A. Martinos Center for Biomedical Imaging · USStellenbosch University · ZA

Funding

Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infantsR01HD093578 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HOLMES, MARTHA, KABA, MAMADOU · 2017 to 2022
$2.9M
Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatallyR01HD085813 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2016 to 2020
$2.3M
NICHD NIH HHS R01 HD085813NICHD NIH HHS R01 HD093578
6 · The paper itself

Abstract

HIV exposed-uninfected (HEU) infants and children are at risk of developmental delays as compared to HIV uninfected unexposed (HUU) populations. The effects of exposure to in utero HIV and ART regimens on the HEU the developing brain are not well understood. In a cohort of 2-week-old newborns, we used diffusion tensor imaging (DTI) tractography and graph theory to examine the influence of HIV and ART exposure in utero on neonate white matter integrity and organisation. The cohort included HEU infants born to mothers who started ART before conception (HEU

Indexed as

HIV InfectionsWhite MatterBrainChildDiffusion Tensor ImagingFemaleHumansInfantInfant, NewbornMothers

Identifiers

PMID38627570
PMCPMC11021525
OpenAlexW4394874025

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.