Evidence map›Paper›PMID 38630294›Full record

ArticleThe Journal of membrane biology2024

Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex.

Chewon Yim, Yeonji Chung, Sungjoon Son, Jeesoo Kim, Jong-Seo Kim, Hyun Kim

Abstract read
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In one paragraph

Article in The Journal of membrane biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chewon Yim *School of Biological Sciences and Institute of Microbiology, Seoul National University, Building 504-421, Seoul, 08826, South Korea.
Yeonji Chung *School of Biological Sciences and Institute of Microbiology, Seoul National University, Building 504-421, Seoul, 08826, South Korea.
Sungjoon SonSchool of Biological Sciences and Institute of Microbiology, Seoul National University, Building 504-421, Seoul, 08826, South Korea.
Jeesoo KimSchool of Biological Sciences and Institute of Microbiology, Seoul National University, Building 504-421, Seoul, 08826, South Korea.
Jong-Seo KimSchool of Biological Sciences and Institute of Microbiology, Seoul National University, Building 504-421, Seoul, 08826, South Korea.
Hyun KimSchool of Biological Sciences and Institute of Microbiology, Seoul National University, Building 504-421, Seoul, 08826, South Korea. joy@snu.ac.kr.
Seoul National University · KRInstitute for Basic Science · KR

Funding

Ministry of Science and Information and Communications Technology of Korea IBS-R008-D1National Research Foundation of Korea NRF-2022R1A2C1010060
6 · The paper itself

Abstract

The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies show that the eukaryotic SPC also cleaves internal transmembrane segments of some membrane proteins, and its non-catalytic subunit, Spc1/SPCS1 plays a critical role in this process. To assess the impact of Spc1 on membrane proteostasis, we carried out quantitative proteomics of yeast cells with and without Spc1. Our data show that the abundance of the membrane proteome in yeast cells lacking Spc1 is in general reduced compared to that in wild-type cells, implicating its role in controlling the cellular levels of membrane proteins.

Indexed as

Membrane ProteinsProteomeSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAspartic Acid EndopeptidasesCell MembraneProteomicsSerine EndopeptidasesAspartic Acid EndopeptidasesMembrane ProteinsProteomeSaccharomyces cerevisiae ProteinsSerine Endopeptidasestype I signal peptidaseMembrane proteinsQuality controlQuantity controlSpc12SPCS1

Identifiers

PMID38630294
OpenAlexW4394873692

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.