ArticleNeurology2024
Trajectories of Occupational Cognitive Demands and Risk of Mild Cognitive Impairment and Dementia in Later Life: The HUNT4 70+ Study.
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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21citing papers in PubMed, 1 pooled it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
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- Associations between occupational trajectories at ages 35-55 and later-life cognition in older adults in Chile.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- [Modifiable risk and protective factors for dementia: an overview of established and emerging evidence].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Review
- Trajectories of late-life job insecurity and labor force participation: Associations with cognitive function and impairment in the Health and Retirement Study's harmonized cognitive assessment protocol.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Theoretical and practical challenges for capturing reserve and resilience in aging and Alzheimer's disease: A narrative review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
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- Timing of retirement and cognitive decline among older black adults: Study of Healthy Aging in African Americans (STAR).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Resting state EEG mediates the association between physical activity and cognitive function in cognitively impaired elderly.Scientific reports · 2026Article
- Occupational social interaction is associated with reduced dementia risk: The Trøndelag Health Study (HUNT).Psychology and aging · 2026Article
- Article
- Prevention of cognitive impairment and dementia in people with Parkinson's disease: A call-to-action.Journal of Parkinson's disease · 2025Review
- Job sector and occupational complexity influence on late-life cognitive function among men.The Gerontologist · 2025Article
- Occupational gaps and mild cognitive impairment among older workers.European geriatric medicine · 2025Article
- Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries.Nature medicine · 2025Article
- Education, Occupational Environment, and Cognitive Function in Later Life.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries.Research square · 2025Article
- Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
16 authors at 1 institution in 1 country.
Trine H EdwinFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.ORCID 0000-0002-0530-8771
Asta K HåbergFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.ORCID 0000-0002-9007-1202
Ekaterina ZotchevaFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.
Bernt BratsbergFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.
Astanand JugessurFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.ORCID 0000-0003-1365-8322
Bo EngdahlFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.
Catherine BowenFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.
Geir SelbækFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.ORCID 0000-0001-6511-8219
Hans-Peter KohlerFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.ORCID 0000-0003-0639-4349
Jennifer R HarrisFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.
Sarah E TomFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.
Steinar KrokstadFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.
Teferi MekonnenFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.
Yaakov SternFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.ORCID 0000-0001-7542-3241
Vegard F SkirbekkFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.ORCID 0000-0002-1647-3246
Bjørn H StrandFrom the Department of Geriatric Medicine (T.H.E., G.S., B.H.S.), Oslo University Hospital; Department for Physical Health and Aging (A.K.H., E.Z., B.E., T.M., V.F.S., B.H.S.), Norwegian Institute of Public Health, Oslo; Department of Neuromedicine and Movement Science (A.K.H.), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Norwegian National Centre for Ageing and Health (E.Z., G.S., V.F.S., B.H.S.), Vestfold Hospital Trust, Tønsberg; Centre for Fertility and Health (B.B., A.J., J.R.H., V.F.S.), Norwegian Institute of Public Health; Ragnar Frisch Center for Economic Research (B.B.), Oslo; Department of Global Public Health and Primary Care (A.J.), University of Bergen, Norway; Independent Researcher (C.B.), Vienna, Austria; Faculty of Medicine (G.S.), University of Oslo, Norway; Population Aging Research Center and Department of Sociology (H.-P.K.), University of Pennsylvania, Philadelphia; Cognitive Neuroscience Division (S.E.T., Y.S.), Department of Neurology, Columbia University, New York; Department of Epidemiology (S.E.T.), Columbia University, Mailman School of Public Health; HUNT Research Centre (S.K.), Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; and Levanger Hospital (S.K.), Nord-Trøndelag Hospital Trust, Norway.ORCID 0000-0003-4385-8886
Norwegian Institute of Public Health · NO
Funding
Changing lives, changing brains: How modern family and work life influences ADRD risksR01AG069109 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STERN, YAAKOV · 2020 to 2025
$3.1MNIA NIH HHS R01 AG069109
Abstract
BACKGROUND AND
objectivesThe cognitive reserve hypothesis posits that cognitively stimulating work delays the onset of mild cognitive impairment (MCI) and dementia. However, the effect of occupational cognitive demands across midlife on the risk of these conditions is unclear.
methodsUsing a cohort study design, we evaluated the association between registry-based trajectories of occupational cognitive demands from ages 30-65 years and clinically diagnosed MCI and dementia in participants in the HUNT4 70+ Study (2017-19). Group-based trajectory modeling identified trajectories of occupational cognitive demands, measured by the routine task intensity (RTI) index (lower RTI indicates more cognitively demanding occupation) from the Occupational Information Network. Multinomial regression was implemented to estimate the relative risk ratios (RRRs) of MCI and dementia, after adjusting for age, sex, education, income, baseline hypertension, obesity, diabetes, psychiatric impairment, hearing impairment, loneliness, smoking status, and physical inactivity assessed at HUNT1-2 in 1984-1986 and 1995-1997. To handle missing data, we used inverse probability weighting to account for nonparticipation in cognitive testing and multiple imputation.
resultsBased on longitudinal RTI scores for 305 unique occupations, 4 RTI trajectory groups were identified (n = 7,003, 49.8% women, age range 69-104 years): low RTI (n = 1,431, 20.4%), intermediate-low RTI (n = 1,578, 22.5%), intermediate-high RTI (n = 2,601, 37.1%), and high RTI (n = 1,393, 19.9%). Participants in the high RTI group had a higher risk of MCI (RRR 1.74, 95% CI 1.41-2.14) and dementia (RRR 1.37, 95% CI 1.01-1.86), after adjusting for age, sex, and education compared with participants in the low RTI group. In a sensitivity analysis, controlling for income and baseline health-related factors, the point estimates were not appreciably changed (RRR 1.66, 95% CI 1.35-2.06 for MCI, and RRR 1.31, 95% CI 0.96-1.78 for dementia). DISCUSSION: People with a history of cognitively stimulating occupations during their 30s, 40s, 50s, and 60s had a lower risk of MCI and dementia older than 70 years, highlighting the importance of occupational cognitive stimulation during midlife for maintaining cognitive function in old age. Further research is required to pinpoint the specific occupational cognitive demands that are most advantageous for maintaining later-life cognitive function.
Indexed as
Cognitive DysfunctionCognitive ReserveDementiaAgedAged, 80 and overCognitionCohort StudiesFemaleHumansMale
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