Evidence map›Paper›PMID 38631806›Full record

ReviewAnnual review of virology2024

The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID.

Abigail S Kane, Madeleine Godfrey, Magali Noval Rivas, Moshe Arditi, Alessio Fasano, Lael M Yonker

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Abigail S KaneChildren's Hospital of Los Angeles, Los Angeles, California, USA.
Madeleine GodfreyMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA; email: lyonker@mgh.harvard.edu.
Magali Noval RivasInfectious and Immunologic Diseases Research Center and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Moshe ArditiInfectious and Immunologic Diseases Research Center and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Alessio FasanoDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Lael M YonkerDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Massachusetts General Hospital · USCedars-Sinai Medical Center · USChildren's Hospital of Los Angeles · US

Funding

Role of IL-1 in Bacterial ligand-induced vasculitis and myocarditisR01AI072726 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2008 to 2020
$4.5M
Microbiome-derived Metabolites Linked to Celiac Disease Onset in Infants at RiskR01DK104344 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FASANO, ALESSIO · 2016 to 2020
$3.4M
Defining neutrophil pathobiology in pediatric Long COVIDR01HL173059 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Lael Yonker · 2024 to 2026
$2.4M
Mechanistically Disentangling the Infected, Inflamed LungK08HL143183 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI YONKER, LAEL · 2018 to 2022
$869k
The Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CD-GEMM) Prospective Cohort StudyR56AI169645 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FASANO, ALESSIO · 2023 to 2023
$823k
NHLBI NIH HHS K08 HL143183NHLBI NIH HHS R01 HL173059NIAID NIH HHS R01 AI072726NIAID NIH HHS R56 AI169645NIDDK NIH HHS R01 DK104344
6 · The paper itself

Abstract

The effects of SARS-CoV-2 infection on children continue to evolve following the onset of the COVID-19 pandemic. Although life-threatening multisystem inflammatory syndrome in children (MIS-C) has become rare, long-standing symptoms stemming from persistent immune activation beyond the resolution of acute SARS-CoV-2 infection contribute to major health sequelae and continue to pose an economic burden. Shared pathophysiologic mechanisms place MIS-C and long COVID within a vast spectrum of postinfectious conditions characterized by intestinal dysbiosis, increased gut permeability, and varying degrees of immune dysregulation. Insights obtained from MIS-C will help shape our understanding of the more indolent and prevalent postacute sequelae of COVID and ultimately guide efforts to improve diagnosis and management of postinfectious complications of SARS-CoV-2 infection in children.

Indexed as

COVID-19DysbiosisPost-Acute COVID-19 SyndromeSARS-CoV-2Systemic Inflammatory Response SyndromeChildGastrointestinal MicrobiomeHumansCOVID-19long COVIDMIS-CPASCspike

Identifiers

PMID38631806
PMCPMC12834129
OpenAlexW4394921730

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.