ArticlemedRxiv : the preprint server for health sciences2024
Gene specific effects on brain volume and cognition of
Open access · greenAbstract readPreprint
In one paragraph
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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Corrections and comments
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Authors and funding
55 authors at 20 institutions in 4 countries.
Marijne VandeberghVIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Eliana Marisa RamosDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nick Corriveau-LecavalierDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Vijay K RamananDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
John KornakDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Carly MesterDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Tyler KolanderDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Danielle BrushaberDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Adam M StaffaroniDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences, San Francisco, CA, USA.
Daniel GeschwindInstitute for Precision Health, Departments of Neurology, Psychiatry and Human Genetics at David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Amy WolfDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences, San Francisco, CA, USA.
Kejal KantarciDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Tania F GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Marleen Van den BroeckVIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Sarah WynantsVIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Matthew C BakerDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Sergi Borrego-ÉcijaAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Fundació Clínic per a la Recerca Biomèdica, Universitat de Barcelona, Barcelona, Spain.
Brian ApplebyDepartment of Neurology, Case Western Reserve University, Cleveland, OH, USA.
Sami BarmadaDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Andrea BozokiDepartment of Neurology, University of North Carolina, Chapel Hill, NC, USA.
David ClarkDepartment of Neurology, Indiana University, Indianapolis, IN, USA.
R Ryan DarbyDepartment of Neurology, Vanderbilt University, Nashville, TN, USA.
Bradford C DickersonDepartment of Neurology, Case Western Reserve University, Cleveland, OH, USA.
Kimiko Domoto-ReillyDepartment of Neurology, University of Washington, Seattle, WA, USA.
Julie A FieldsDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Douglas R GalaskoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Nupur GhoshalDepartments of Neurology and Psychiatry, Washington University School of Medicine, Washington University, St. Louis, MO, USA.
Neill Graff-RadfordDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Ian M GrantDepartment of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Lawrence S HonigTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA.
Ging-Yuek Robin HsiungDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Edward D HueyDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
David IrwinDepartment of Neurology and Penn Frontotemporal Degeneration Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David S KnopmanDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Justin Y KwanNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Gabriel C LégerDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Irene LitvanDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Joseph C MasdeuDepartment of Neurology, Houston Methodist, Houston, TX, USA.
Mario F MendezDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Chiadi OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Belen PascualDepartment of Neurology, Houston Methodist, Houston, TX, USA.
Peter PressmanDepartment of Neurology, University of Colorado, Aurora, CO, USA.
Aaron RitterCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, 89106, USA.
Erik D RobersonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Allison SnyderNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Anna Campbell SullivanGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio.
M Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Dylan WintCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, 89106, USA.
Hilary W HeuerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences, San Francisco, CA, USA.
Leah K ForsbergDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Adam L BoxerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences, San Francisco, CA, USA.
Howard J RosenDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences, San Francisco, CA, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Rosa RademakersVIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID 0000-0002-4049-0863
Mayo Clinic in Florida · USUniversity of California, San Francisco · USMayo Clinic · USMayo Clinic in Arizona · USUniversity of Antwerp · BEUniversity of California, Los Angeles · USUniversity of California San Diego · USCase Western Reserve University · USCleveland Clinic · USHouston Methodist · USNational Institutes of Health · USBrown University · USColumbia University · USHospital Clínic de Barcelona · ESIndiana University – Purdue University Indianapolis · USInstitute for Neurodegenerative Disorders · USJohns Hopkins University · USNorthwestern University · USUniversity of Alabama at Birmingham · USUniversity of British Columbia · CA
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$120.9MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MUCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMES B BREWER · 2019 to 2026
$34.9MResearch Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3MThe Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MDementia with Lewy Bodies Consortium - Supplement for ASL sequenceU01NS100610 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI DOUGLAS R GALASKO, JAMES Bruce LEVERENZ · 2016 to 2026
$15.6MClinical Coordination Center for STEADY-PD3U01NS080818 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SIMUNI, TANYA · 2014 to 2018
$13.0MTraining - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4MGenetic basis of neuropsychiatric symptoms in Alzheimer's diseaseU01AG079850 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, Edward D Huey · 2023 to 2026
$3.0MNeuroanatomical associations with the factor structure underlying neuropsychiatric symptoms in Alzheimer's diseaseR01AG062268 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUEY, EDWARD D · 2018 to 2022
$2.5MTraining in Research to Assure Neuroscience Scholars Cultivate Expertise in Notable Disparities Science (TRANSCENDS)R25NS098999 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BRUCE OVBIAGELE · 2017 to 2026
$2.5MNIA NIH HHS K23 AG061253NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG062268NIA NIH HHS U01 AG045390NIA NIH HHS U01 AG079850NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NIMH NIH HHS R01 MH120794NINDS NIH HHS R21 NS114764NINDS NIH HHS R25 NS098999NINDS NIH HHS U01 NS080818NINDS NIH HHS U01 NS100610NINDS NIH HHS U54 NS092089
Abstract
Background and Objectives: Methods: Participants were enrolled through the ARTFL/LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study, which includes symptomatic and presymptomatic individuals with a pathogenic mutation in Results: The minor allele of Discussion: We identified associations of
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What Socratic holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.