Evidence map›Paper›PMID 38634133›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Effect of the DASH diet on the sodium-chloride cotransporter and aquaporin-2 in urinary extracellular vesicles.

Dana Bielopolski, Luca Musante, Ewout J Hoorn, Henrik Molina, Douglas Barrows, Thomas S Carrol, Michael A Harding, Samantha Upson, Adam Qureshi, Max M Weder and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Uromodulin and the study of urinary extracellular vesicles.Journal of extracellular biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Dana BielopolskiThe Rockefeller University Center for Clinical and Translational Science, New York, New York, United States.ORCID 0000-0001-9476-0032
Luca MusanteSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0003-0845-275X
Ewout J HoornDivision of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-8738-3571
Henrik MolinaProteomics Resource Center, Rockefeller University, New York, New York, United States.
Douglas BarrowsBioinformatics Resource Center, Rockefeller University, New York, New York, United States.
Thomas S CarrolBioinformatics Resource Center, Rockefeller University, New York, New York, United States.
Michael A HardingDivision of Nephrology, Department of Medicine, University of Virginia at Charlottesville, Charlottesville, Virginia, United States.
Samantha UpsonDivision of Nephrology, Department of Medicine, University of Virginia at Charlottesville, Charlottesville, Virginia, United States.ORCID 0009-0003-5899-5565
Adam QureshiThe Rockefeller University Center for Clinical and Translational Science, New York, New York, United States.
Max M WederDivision of Pulmonology, Department of Medicine, University of Virginia at Charlottesville, Charlottesville, Virginia, United States.ORCID 0000-0002-9453-9263
Jonathan N TobinThe Rockefeller University Center for Clinical and Translational Science, New York, New York, United States.
Rhonda G KostThe Rockefeller University Center for Clinical and Translational Science, New York, New York, United States.ORCID 0000-0002-5419-0589
U ErdbrüggerDivision of Nephrology, Department of Medicine, University of Virginia at Charlottesville, Charlottesville, Virginia, United States.
Rockefeller University · USUniversity of Virginia · USClinical Directors Network · USErasmus MC · NLUniversity of Pennsylvania · US

Funding

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
American Diabetes Association (ADA) XXXEC | ERC | HORIZON EUROPE European Research Council (ERC) UL1 TR001866.HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1 TR001866.National Kidney Foundation (NKF) XXXXNCATS NIH HHS UL1 TR001866
6 · The paper itself

Abstract

The dietary approach to stop hypertension (DASH) diet combines the antihypertensive effect of a low sodium and high potassium diet. In particular, the potassium component of the diet acts as a switch in the distal convoluted tubule to reduce sodium reabsorption, similar to a diuretic but without the side effects. Previous trials to understand the mechanism of the DASH diet were based on animal models and did not characterize changes in human ion channel protein abundance. More recently, protein cargo of urinary extracellular vesicles (uEVs) has been shown to mirror tissue content and physiological changes within the kidney. We designed an inpatient open label nutritional study transitioning hypertensive volunteers from an American style diet to DASH diet to examine physiological changes in adults with stage 1 hypertension otherwise untreated (Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obarzanek E, Conlin PR, Miller ER 3rd, Simons-Morton DG, Karanja N, Lin PH; DASH-Sodium Collaborative Research Group.

Indexed as

Aquaporin 2Extracellular VesiclesAdultBlood PressureDietary Approaches To Stop HypertensionDiet, Sodium-RestrictedFemaleHumansHypertensionKidneyMaleMiddle AgedProteomicsSodium Chloride SymportersSolute Carrier Family 12, Member 3AQP2 protein, humanAquaporin 2SLC12A3 protein, humanSodium Chloride SymportersSolute Carrier Family 12, Member 3AQP2DASH dietextracellular vesiclesNCCproteomic analysis

Identifiers

PMID38634133
PMCPMC11386975
OpenAlexW4394920840

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.