ArticleAmerican journal of physiology. Renal physiology2024
Influence of proteolytic cleavage of ENaC's γ subunit upon Na
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Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
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Who cites it
13 citing papers in PubMed, 8 citations in OpenAlex.
- Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ-Subunit of the Epithelial Sodium Channel During Sodium Restriction.Acta physiologica (Oxford, England) · 2026Article
- ENaC processing in rat kidney: effects of salt loading and ADH.American journal of physiology. Renal physiology · 2026Article
- Guinea pig δβγ-ENaC is locked in an open state and uncoupled from regulation by proteases.Pflugers Archiv : European journal of physiology · 2026Article
- Kidney kallikrein-1 contributes to cleavage of γ-ENaC in vivo.American journal of physiology. Renal physiology · 2026Article
- Contribution of murine strain background to NabioRxiv : the preprint server for biology · 2026Article
- Resistance to doxorubicin-induced proteinuria and proteolytic activation of ENaC in 129S2/SvPas mice.Physiological reports · 2025Article
- Kidney kallikrein-1 contributes to cleavage of gamma-ENaCbioRxiv : the preprint server for biology · 2025Article
- Acute activation of human epithelial sodium channel (ENaC) by serum and glucocorticoid inducible kinase 1 (SGK1) requires prior cleavage of the channel's γ-subunit at its proximal cleavage site.Pflugers Archiv : European journal of physiology · 2025Article
- Transmembrane Serine Protease 2 and Proteolytic Activation of the Epithelial Sodium Channel in Mouse Kidney.Journal of the American Society of Nephrology : JASN · 2025Article
- Thick Ascending Limb Specific Inactivation of Myh9 and Myh10 Myosin Motors Results in Progressive Kidney Disease and Drives Sex-specific Cellular Adaptation in the Distal Nephron and Collecting Duct.Function (Oxford, England) · 2025Article
- Epithelial Na+ Channels, Immune Cells, and Salt.Annual review of physiology · 2025Review
- Going with the flow: New insights regarding flow induced KPhysiological reports · 2024Review
- Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following NaThe Journal of physiology · 2024Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Evan C RayRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-1491-4869
Andrew NickersonRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0001-7604-2344
Shaohu ShengRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-7198-1702
Rolando Carrisoza-GaytanDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York City, New York, United States.
Tracey LamRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Allison MarciszynRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Lei ZhangRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Alexa JordahlRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Chunming BiDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Aaliyah WinfreyRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Zhaohui KouDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Sebastien GingrasDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Annet KiraboDepartment of Medicine, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0001-8580-9359
Lisa M SatlinDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York City, New York, United States.ORCID 0000-0002-1744-1748
Thomas R KleymanRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-2413-5415
University of Pittsburgh · USIcahn School of Medicine at Mount Sinai · USVanderbilt University · US
Funding
University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3MSingle Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4MResource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerard L Apodaca · 2023 to 2026
$4.8MENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6MRenal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1MRole of piezo channels in intercalated cellsR01DK129285 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R, SATLIN, LISA M. · 2022 to 2025
$2.3MProteolytic activation of ENaC in Proteinuric Kidney DiseaseK08DK110332 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, EVAN CROSS · 2016 to 2021
$903kNCATS NIH HHS UL1 TR001857NHLBI NIH HHS R01 HL147818NIDDK NIH HHS K08 DK110332NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK129285NIDDK NIH HHS T32 DK061296NIDDK NIH HHS U54 DK137329
Abstract
The epithelial Na
Indexed as
Epithelial Sodium ChannelsProteolysisSodiumAmilorideAnimalsColonDiet, Sodium-RestrictedFemaleFurinHomeostasisKidney Tubules, CollectingMaleMiceMice, 129 StrainMutationPotassiumAmilorideEpithelial Sodium ChannelsFurinPotassiumScnn1g protein, mouseSodiumcleavageENaCfurinNa+ homeostasisproteaseproteinuria
Identifiers
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.