Evidence map›Paper›PMID 38634411›Full record

ArticleJournal of diabetes investigation2024

Long-term efficacy of encapsulated xenogeneic islet transplantation: Impact of encapsulation techniques and donor genetic traits.

Heon-Seok Park, Eun Young Lee, Young-Hye You, Marie Rhee, Jong-Min Kim, Seong-Soo Hwang, Poong-Yeon Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. GHRH in diabetes and metabolism.Reviews in endocrine & metabolic disorders · 2025
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Heon-Seok ParkDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID https://orcid.org/0000-0001-7587-6929
Eun Young LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID https://orcid.org/0000-0002-4968-5026
Young-Hye YouDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID https://orcid.org/0000-0002-2548-6524
Marie RheeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID https://orcid.org/0000-0001-9507-902X
Jong-Min KimXenotransplantation Research Center, Seoul National University College of Medicine, Seoul, South Korea.ORCID https://orcid.org/0000-0003-0906-0117
Seong-Soo HwangAnimal Biotechnology Division, National Institute of Animal Science, Rural Development Administration, Wanju-gun, Jeonbuk-do, South Korea.
Poong-Yeon LeeAnimal Biotechnology Division, National Institute of Animal Science, Rural Development Administration, Wanju-gun, Jeonbuk-do, South Korea.
The Catholic University of Korea Seoul St. Mary's Hospital · KRRural Development Administration · KRSeoul National University · KR

Funding

Basic Science Research Program through the NRF funded by the Ministry of Education 2022R1I1A1A01053763Cooperative Research Program for Agriculture Science and Technology Development funded by Rural Development Administration PJ01345301Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare HI13C0954National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) 2021R1C1C1013016Technology Innovation Program funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea) 141584934
6 · The paper itself

Abstract

AIMS/

introductionTo investigate the long-term efficacy of various encapsulated xenogeneic islet transplantation, and to explore the impact of different donor porcine genetic traits on islet transplantation outcomes. MATERIALS AND

methodsDonor porcine islets were obtained from wild-type, α1,3-galactosyltransferase knockout (GTKO) and GTKO with overexpression of membrane cofactor protein genotype. Naked, alginate, alginate-chitosan (AC), alginate-perfluorodecalin (A-PFD) and AC-perfluorodecalin (AC-PFD) encapsulated porcine islets were transplanted into diabetic mice.

resultsIn vitro assessments showed no differences in the viability and function of islets across encapsulation types and donor porcine islet genotypes. Xenogeneic encapsulated islet transplantation with AC-PFD capsules showed the most favorable long-term outcomes, maintaining normal blood glucose levels for 180 days. A-PFD capsules showed comparable results to AC-PFD capsules, followed by AC capsules and alginate capsules. Conversely, blood glucose levels in naked islet transplantation increased to >300 mg/dL within a week after transplantation. Naked islet transplantation outcomes showed no improvement based on donor islet genotype. However, alginate or AC capsules showed delayed increases in blood glucose levels for GTKO and GTKO with overexpression of membrane cofactor protein porcine islets compared with wild-type porcine islets.

conclusionThe AC-PFD capsule, designed to ameliorate both hypoxia and inflammation, showed the highest long-term efficacy in xenogeneic islet transplantation. Genetic modifications of porcine islets with GTKO or GTKO with overexpression of membrane cofactor protein did not influence naked islet transplantation outcomes, but did delay graft failure when encapsulated.

Indexed as

Diabetes Mellitus, ExperimentalIslets of Langerhans TransplantationTransplantation, HeterologousAlginatesAnimalsBlood GlucoseGalactosyltransferasesGenotypeGraft SurvivalIslets of LangerhansMaleMiceSwineTissue DonorsAlginatesBlood GlucoseGalactosyltransferasesCell encapsulationGene editingIslets of Langerhans transplantation

Identifiers

PMID38634411
PMCPMC11143419
OpenAlexW4394921499

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.