Evidence map›Paper›PMID 38635757›Full record

ArticleBlood2024

Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner.

Aikaterini Karagianni, Anastasia Iris Karkempetzaki, Daniel Brooks, Shinobu Matsuura, Vrinda Dambal, Philip C Trackman, Katya Ravid

Open access · greenAbstract read
In one paragraph

Article in Blood, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Aikaterini KaragianniDepartment of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0000-0002-8247-4132
Anastasia Iris KarkempetzakiDepartment of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Daniel BrooksCenter for Musculoskeletal Research, Endocrine Unit, Massachusetts General Hospital, Boston, MA.
Shinobu MatsuuraDepartment of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0000-0002-3914-5376
Vrinda DambalDepartment of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA.ORCID 0000-0002-5843-6523
Philip C TrackmanDepartment of Translational Dental Medicine, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA.
Katya RavidDepartment of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.ORCID 0000-0002-9918-3024
Boston University · USBeth Israel Deaconess Medical Center · US

Funding

Translational Imaging and Phenotyping CoreP30AR075042 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Marie Demay · 2019 to 2026
$7.4M
A path to thrombosis in primary myelofibrosisR01HL136363 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAVID, KATYA · 2018 to 2021
$1.9M
Megakaryocyte Mechanosensing Toward Platelet BiogenesisR01HL158670 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAVID, KATYA · 2021 to 2024
$1.6M
The bone marrow extracellular matrix: scaffold of hematopoiesisK01OD025290 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MATSUURA, SHINOBU · 2019 to 2023
$611k
Targeting beta1 integrin in JAK2V617F+ stem cellsR03OD031959 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MATSUURA, SHINOBU · 2023 to 2024
$248k
NHLBI NIH HHS R01 HL136363NHLBI NIH HHS R01 HL158670NIAMS NIH HHS P30 AR075042NIH HHS K01 OD025290NIH HHS R03 OD031959
6 · The paper itself

Abstract

abstractLysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.

Indexed as

MegakaryocytesMice, KnockoutProtein-Lysine 6-OxidaseAnimalsBone and BonesCollagenExtracellular Matrix ProteinsFemaleGene DeletionMaleMiceSex CharacteristicsSex FactorsCollagenExtracellular Matrix ProteinsLox protein, mouseProtein-Lysine 6-Oxidase

Identifiers

PMID38635757
PMCPMC11196861
OpenAlexW4394933639

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.