Evidence map›Paper›PMID 38639491›Full record

ArticleAntimicrobial agents and chemotherapy2024

Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs.

Angélica M Rosado-Quiñones, Emilee E Colón-Lorenzo, Zarna Rajeshkumar Pala, Jürgen Bosch, Karl Kudyba, Heather Kudyba, Susan E Leed, Norma Roncal, Abel Baerga-Ortiz, Abiel Roche-Lima and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Revisiting Glutathione Transferases ofPharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Angélica M Rosado-QuiñonesDepartment of Microbiology and Medical Zoology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Emilee E Colón-LorenzoDepartment of Microbiology and Medical Zoology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Zarna Rajeshkumar PalaLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Jürgen BoschCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.
Karl KudybaDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Heather KudybaLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Susan E LeedDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Norma RoncalDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Abel Baerga-OrtizDepartment of Biochemistry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Abiel Roche-LimaRCMI Program, Medical Science Campus, University of Puerto Rico, San Juan, Puerto Rico.
Yamil GerenaDepartment of Pharmacology and Toxicology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
David A FidockDepartment of Microbiology and Immunology, Columbia University, New York, New York, USA.
Alison RothDepartment of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Joel Vega-Rodríguez *Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID 0000-0002-9576-0058
Adelfa E Serrano *Department of Microbiology and Medical Zoology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.ORCID 0000-0001-5929-9973
University of Puerto Rico, Medical Sciences Campus · PRWalter Reed Army Institute of Research · USNational Institutes of Health · USUniversity of Puerto Rico System · PRCenter for Global Health · USColumbia University Irving Medical Center · US

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Emma Fernandez-Repollet · 2017 to 2026
$35.8M
Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) 5R25GM061151-22HHS | NIH | National Institute on Minority Health and Health Disparities (NIMHD) U54MD007600HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) AI001250-01NIGMS NIH HHS R25 GM061151NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

The development of novel antiplasmodial compounds with broad-spectrum activity against different stages of

Indexed as

AntimalarialsDrug SynergismHydrazonesPlasmodium bergheiPlasmodium falciparumAnimalsFemaleHep G2 CellsHumansMalariaMaleMicePlasmodium cynomolgiPlasmodium vivaxAntimalarialsHydrazonesdrug combinationsmalariamultistage activityPlasmodium bergheiPlasmodium falciparum

Identifiers

PMID38639491
PMCPMC11620517
OpenAlexW4394942435

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.