Evidence map›Paper›PMID 38639853›Full record

ArticleJournal of neuro-oncology2024

Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse.

Kevin J Bielamowicz, Mary Beth Littrell, Gregory W Albert, Lora S Parker, Sateesh Jayappa, Kenneth Aldape, Murat Gokden

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Kevin J BielamowiczDivision of Pediatrics, The University of Arkansas for Medical Sciences (UAMS), 1 Children's Way Slot 512-10, 72223, Little Rock, AR, USA. kjbielamowicz2@uams.edu.
Mary Beth LittrellDivision of Pediatrics, The University of Arkansas for Medical Sciences (UAMS), 1 Children's Way Slot 512-10, 72223, Little Rock, AR, USA.
Gregory W AlbertDepartment of Neurosurgery, UAMS, Little Rock, AR, USA.
Lora S ParkerArkansas Children's Hospital, Little Rock, AR, USA.
Sateesh JayappaDivision of Radiology, UAMS, Little Rock, AR, USA.
Kenneth AldapeLaboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.
Murat GokdenDivision of Pathology, UAMS, Little Rock, AR, USA.
Arkansas Children's Hospital · USArkansas Department of Agriculture · USNational Cancer Institute · USUniversity of Arkansas for Medical Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCentral nervous system (CNS) embryonal tumors are a diverse group of malignant tumors typically affecting pediatric patients that recently have been better defined, and this paper describes evolution of a unique type of embryonal tumor at relapse.

methodsTwo pediatric patients with CNS embryonal tumors with EWSR1-PLAGL1 rearrangements treated at Arkansas Children's Hospital with histopathologic and molecular data are described.

resultsThese two patients at diagnosis were classified as CNS embryonal tumors with EWSR1-PLAGL1 rearrangements based on histologic appearance and molecular data. At relapse both patient's disease was reclassified as atypical teratoid rhabdoid tumor (ATRT) based on loss of INI-1, presence of SMARCB1 alterations, and methylation profiling results.

conclusionCNS embryonal tumors with EWSR1-PLAGL1 rearrangements acquire or include a population of cells with SMARCB1 alterations that are the component that predominate at relapse, suggesting treatment aimed at this disease component at diagnosis should be considered.

Indexed as

Central Nervous System NeoplasmsNeoplasm Recurrence, LocalNeoplasms, Germ Cell and EmbryonalRNA-Binding Protein EWSSMARCB1 ProteinCell Cycle ProteinsFemaleGene RearrangementHumansInfantMaleRhabdoid TumorTranscription FactorsTumor Suppressor ProteinsCell Cycle ProteinsEWSR1 protein, humanPLAGL1 protein, humanRNA-Binding Protein EWSSMARCB1 ProteinSMARCB1 protein, humanTranscription FactorsTumor Suppressor ProteinsAtypical teratoid rhabdoid tumorsBrain tumorEmbryonal tumorsEWSR1-PLAGL1 rearrangementsINI-1 deficient tumors

Identifiers

PMID38639853
PMCPMC11147842
OpenAlexW4394957669

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.