Evidence map›Paper›PMID 38639995›Full record

ArticleeLife2024

A modified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced protection against tuberculosis in mice.

Moagi Tube Shaku, Peter K Um, Karl L Ocius, Alexis J Apostolos, Marcos M Pires, William R Bishai, Bavesh D Kana

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Targeting Outer Membrane Vesicles ofJournal of microbiology and biotechnology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Activity Profiling of Mycobacterial L,D-Transpeptidases.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Moagi Tube ShakuDST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-1171-7950
Peter K UmCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0001-8215-9493
Karl L OciusDepartment of Chemistry, University of Virginia, Charlottesville, United States.
Alexis J ApostolosDepartment of Chemistry, University of Virginia, Charlottesville, United States.
Marcos M PiresDepartment of Chemistry, University of Virginia, Charlottesville, United States.
William R BishaiCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-8734-4118
Bavesh D KanaDST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-9713-3480
University of Virginia · USNational Health Laboratory Service · ZA

Funding

A STINGing vaccine for TBR01AI155346 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES, MEHRA, SMRITI · 2020 to 2024
$4.9M
Howard Hughes Medical Institute HHMI000NIAID NIH HHS R01 AI155346NIH HHS NIH AI 155346
6 · The paper itself

Abstract

Mechanisms by which

Indexed as

BCG VaccineMycobacterium tuberculosisPeptidoglycanTuberculosisAnimalsBacterial ProteinsDisease Models, AnimalFemaleHumansMacrophagesMiceMice, Inbred C57BLNod1 Signaling Adaptor ProteinBacterial ProteinsBCG VaccineNod1 Signaling Adaptor ProteinPeptidoglycanamidationinfectious diseasemicrobiologymousemycobacteriumNOD1peptidoglycanrecombinant BCG vaccinetuberculosis

Identifiers

PMID38639995
PMCPMC11132681
OpenAlexW4394952507

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.