Evidence map›Paper›PMID 38640241›Full record

ArticleScience advances2024

Coin-sized, fully integrated, and minimally invasive continuous glucose monitoring system based on organic electrochemical transistors.

Jing Bai, Dingyao Liu, Xinyu Tian, Yan Wang, Binbin Cui, Yilin Yang, Shilei Dai, Wensheng Lin, Jixiang Zhu, Jinqiang Wang and 3 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Bioelectronic Considerations in Biomedical Microneedles.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jing BaiDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.ORCID 0000-0002-9116-0768
Dingyao LiuDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.ORCID 0009-0008-3006-0473
Xinyu TianDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.ORCID 0009-0009-1522-5951
Yan WangDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Binbin CuiDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Yilin YangDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.ORCID 0000-0002-4935-5617
Shilei DaiDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Wensheng LinDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.ORCID 0009-0002-7330-3793
Jixiang ZhuSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China.
Jinqiang WangState Key Laboratory of Advanced Drug Delivery Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.ORCID 0000-0002-0048-838X
Aimin XuState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.ORCID 0000-0002-0668-033X
Zhen GuState Key Laboratory of Advanced Drug Delivery Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.ORCID 0000-0003-2947-4456
Shiming ZhangDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.ORCID 0000-0002-9727-028X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuous glucose monitoring systems (CGMs) are critical toward closed-loop diabetes management. The field's progress urges next-generation CGMs with enhanced antinoise ability, reliability, and wearability. Here, we propose a coin-sized, fully integrated, and wearable CGM, achieved by holistically synergizing state-of-the-art interdisciplinary technologies of biosensors, minimally invasive tools, and hydrogels. The proposed CGM consists of three major parts: (i) an emerging biochemical signal amplifier, the organic electrochemical transistor (OECT), improving the signal-to-noise ratio (SNR) beyond traditional electrochemical sensors; (ii) a microneedle array to facilitate subcutaneous glucose sampling with minimized pain; and (iii) a soft hydrogel to stabilize the skin-device interface. Compared to conventional CGMs, the OECT-CGM offers a high antinoise ability, tunable sensitivity and resolution, and comfort wearability, enabling personalized glucose sensing for future precision diabetes health care. Last, we discuss how OECT technology can help push the limit of detection of current wearable electrochemical biosensors, especially when operating in complicated conditions.

Indexed as

Biosensing TechniquesDiabetes MellitusBlood GlucoseBlood Glucose Self-MonitoringContinuous Glucose MonitoringGlucoseHumansReproducibility of ResultsBlood GlucoseGlucose

Identifiers

PMID38640241
PMCPMC11029813

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.