Evidence map›Paper›PMID 38641407›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.

Christin Hanke-Gogokhia, Thomas E Zapadka, Stella Finkelstein, Mikael Klingeborn, Timothy K Maugel, Joshua H Singer, Vadim Y Arshavsky, Jonathan B Demb

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christin Hanke-GogokhiaDepartments of Ophthalmology & Visual Science, Yale University, New Haven, Connecticut 06511.
Thomas E ZapadkaDepartments of Ophthalmology & Visual Science, Yale University, New Haven, Connecticut 06511.ORCID 0000-0002-5559-4630
Stella FinkelsteinDepartment of Ophthalmology, Duke University School of Medicine, Durham, North Carolina 27705.
Mikael KlingebornDepartment of Ophthalmology, Duke University School of Medicine, Durham, North Carolina 27705.
Timothy K MaugelDepartment of Biology, University of Maryland, College Park, Maryland 20742.ORCID 0000-0003-3754-0871
Joshua H SingerDepartment of Biology, University of Maryland, College Park, Maryland 20742.ORCID 0000-0002-0561-2247
Vadim Y ArshavskyDepartment of Ophthalmology, Duke University School of Medicine, Durham, North Carolina 27705 jonathan.demb@yale.edu vadim.arshavsky@duke.edu.ORCID 0000-0001-8394-3650
Jonathan B DembDepartments of Ophthalmology & Visual Science, Yale University, New Haven, Connecticut 06511 jonathan.demb@yale.edu vadim.arshavsky@duke.edu.ORCID 0000-0003-2227-9041
Duke University · USYale University · USUniversity of Maryland, College Park · US

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Modulation of Exosome Release for Functional Restoration in Age-related Retinal DisordersP20GM152335 · NIGMS · MC LAUGHLIN RESEARCH INSTITUTE · PI Moses Leavens · 2024 to 2026
$11.1M
Synaptic Transmission in The Rod Pathway of the Mammalian RetinaR01EY017836 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI Jonathan B Demb, Anastas Popratiloff · 2007 to 2026
$7.2M
Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI Jonathan B Demb · 2016 to 2026
$7.1M
Neural Circuits and Synapses for Early Visual ProcessingR01EY014454 · NEI · YALE UNIVERSITY · PI DEMB, JONATHAN B · 2005 to 2022
$6.7M
Mechanisms of photoreceptor disc maturationR01EY030451 · NEI · DUKE UNIVERSITY · PI ARSHAVSKY, VADIM Y · 2020 to 2024
$2.4M
The Role of RPE-derived Exosomes in Deposit Formation and ECM ModulationR21EY033057 · NEI · MC LAUGHLIN RESEARCH INSTITUTE · PI KLINGEBORN, MIKAEL · 2021 to 2022
$447k
Retinal Circuitry Response to Nerve InjuryF31EY034776 · NEI · YALE UNIVERSITY · PI ZAPADKA, THOMAS EUGENE · 2023 to 2025
$146k
NEI NIH HHS F31 EY034776NEI NIH HHS P30 EY005722NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY014454NEI NIH HHS R01 EY017836NEI NIH HHS R01 EY030451NEI NIH HHS R21 EY033057NIGMS NIH HHS P20 GM152335
6 · The paper itself

Abstract

Vertebrate vision begins with light absorption by rod and cone photoreceptors, which transmit signals from their synaptic terminals to second-order neurons: bipolar and horizontal cells. In mouse rods, there is a single presynaptic ribbon-type active zone at which the release of glutamate occurs tonically in the dark. This tonic glutamatergic signaling requires continuous exo- and endocytosis of synaptic vesicles. At conventional synapses, endocytosis commonly requires dynamins: GTPases encoded by three genes (

Indexed as

Dynamin IDynamin IIIElectroretinographyMice, KnockoutRetinal Rod Photoreceptor CellsSynapsesAnimalsFemaleMaleMiceMice, Inbred C57BLDynamin IDynamin IIIdynaminendocytosisretinaribbonrod photoreceptorsynapse

Identifiers

PMID38641407
PMCPMC11209669
OpenAlexW4394951113

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.