Evidence map›Paper›PMID 38644875›Full record

ArticleHeliyon2024

Huanglian Jiedu decoction alleviates neurobehavioral damage in mice with chronic alcohol exposure through the RAS-RAF-MEK-ERK pathway.

Yun Chen, Lianyan Jiang, Mao Li, Yuling Shen, Shanyu Liu, Dongdong Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yun ChenDepartment of Neurology, Chengdu University of Traditional Chinese Medicine, Sichuan, PR China.
Lianyan JiangDepartment of Neurology, Chengdu University of Traditional Chinese Medicine, Sichuan, PR China.
Mao LiDepartment of Neurology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, PR China.
Yuling ShenDepartment of Neurology, Chengdu University of Traditional Chinese Medicine, Sichuan, PR China.
Shanyu LiuDepartment of Neurology, Chengdu University of Traditional Chinese Medicine, Sichuan, PR China.
Dongdong YangDepartment of Neurology, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Sichuan, PR China.
Chengdu University of Traditional Chinese Medicine · CNFirst Affiliated Hospital of Henan University of Traditional Chinese Medicine · CNThe First People's Hospital of Guiyang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Long-term alcohol consumption can cause organic damage to the brain, resulting in mental and nervous system abnormalities and intellectual impairment. Huanglian Jiedu decoction (HLJDD) is the classic representative of clearing heat and detoxifying. This study aimed to explore the effects and possible mechanisms of HLJDD on brain injury in chronic alcohol-exposed mice. Methods: The alcohol-exposed mice were treated with different doses of HLJDD to observe behavioral changes, hippocampal Aβ Results: Chronic alcohol exposure reduced body weight in mice, led to motor cognitive impairment, increased Aβ Conclusion: HLJDD may ameliorate brain damage caused by chronic alcohol exposure by regulating the RAS-RAF-MEK-ERK pathway.

Indexed as

Behavioral changeChronic alcohol exposureHuanglian jiedu decoctionRAS-RAF-MEK-ERK pathwayTranscriptome sequencing

Identifiers

PMID38644875
PMCPMC11033144
OpenAlexW4394770477

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.