Evidence map›Paper›PMID 38645014›Full record

ArticleResearch square2024

Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency.

Zoltan Szallasi, Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nuosome, Claire Kuo and 25 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 14 institutions in 6 countries.

Zoltan SzallasiChildren's Hospital Boston.
Miklos DiossyDanish Cancer Society Research Center.ORCID 0000-0003-0308-6615
Viktoria TiszaInstitute of Enzymology, Research Centre for Natural Sciences.
Hua LiCenter for Prostate Cancer Research.
Pranshu SahgalDana-Farber Cancer Institute and Harvard Medical School.ORCID 0000-0002-9857-3987
Jia ZhouDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Zsofia SztupinszkiDanish Cancer Society Research Center.
Denise YoungCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
Darryl NuosomeCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
Claire KuoCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
Jiji JiangCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
Yongmei ChenCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department Uniformed Services University of the Health Sciences, Bethesda, MD.
Reinhard EbnerCytoTest Inc., Rockville, Maryland, USA.
Isabell SesterhennJoint Pathology Center, Silver Spring, Maryland, USA.
Joel MoncurJoint Pathology Center, Silver Spring, Maryland, USA.
Gregory ChesnutCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department Uniformed Services University of the Health Sciences, Bethesda, MD.
Gyorgy PetrovicsComputational Health Informatics Program, Boston Children's Hospital, USA, Harvard Medical School, Boston, USA.
Gregory T KlusComputational Health Informatics Program.
Gábor ValczELKH Translational Extracellular Vesicle Research Group, Budapest, Hungary.
Pier NuzzoDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Dezso RibliDepartment of Physics of Complex Systems, Eotvos Lorand University, Budapest, Hungary.
Judit BörcsökDanish Cancer Society Research Center.ORCID 0000-0002-3290-3971
Aurél PrószDanish Cancer Institute.
Marcin KrzystanekDanish Cancer Society Research Center.
Thomas RiedNational Cancer Institute.
Dávid SzütsHUN-REN Research Centre for Natural Sciences.ORCID 0000-0001-7985-0136
Kinza RizwanDepartment of Medicine, Baylor College of Medicine, Houston, USA.
Salma KaocharDepartment of Medicine, Baylor College of Medicine, Houston, USA.
Shailja PathaniaUniversity of Massachusetts Boston.
Alan D'AndreaDana-Farber Cancer Institute.ORCID 0000-0001-6168-6294
István CsabaiEötvös Loránd University.ORCID 0000-0001-9232-9898
Shib SrivastavaCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
Matthew FreedmanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Albert DobiCenter for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
Sandor SpisakInstitute of Enzymology, Research Centre for Natural Sciences, Eötvös Loránd Research Network.
Uniformed Services University of the Health Sciences · USDanish Cancer Society · DKDana-Farber Cancer Institute · USBaylor College of Medicine · USEötvös Loránd University · HUHarvard University · USInstitute of Molecular Life Sciences · HUBoston Children's Museum · USBoston University · USCancer Institute (WIA) · INHUN-REN Research Centre for Natural Sciences · HUMontavid Thermodynamic Research Group · HUProstate Cancer Research · GBUniversity of Massachusetts Boston · US

Funding

The Impact of DNA Damage Repair Abnormalities in Prostate CancerP01CA228696 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SOLIT, DAVID B. · 2019 to 2024
$8.7M
NCI NIH HHS P01 CA228696
6 · The paper itself

Abstract

We analyzed genomic data derived from the prostate cancer of African and European American men in order to identify differences that may contribute to racial disparity of outcome and that could also define novel therapeutic strategies. In addition to analyzing patient derived next generation sequencing data, we performed FISH based confirmatory studies of Chromodomain helicase DNA-binding protein 1 (

Identifiers

PMID38645014
PMCPMC11030533
OpenAlexW4393373448

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.