ArticleResearch square2024
Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome.
Douglas Thomas, Marianne Palczewski, Hannah Kuschman, Brian Hoffman, Hao Yang, Sharon Glynn, David Wilson, Eric Kool, William Montfort, Jenny Chang and 10 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors at 10 institutions in 3 countries.
Marianne PalczewskiUniversity of Illinois Chicago, College of Pharmacy, Department of Pharmaceutical Sciences.ORCID 0000-0003-4957-2387 Hannah KuschmanUniversity of Illinois Chicago, College of Pharmacy, Department of Pharmaceutical Sciences.
Hao YangWeinberg College of Arts and Sciences, Northwestern University, Department of Chemistry.
Sharon GlynnUniversity of Galway, College of Medicine, Nursing and Health Sciences, School of Medicine, D. of Pathology.
David WilsonStanford University.
Eric KoolStanford University, Department of Chemistry, School of Humanities and Sciences.
Jenny ChangHouston Methodist, Department of Medicine and Oncology, Weill Cornell Medical College.
Aydolun PetenkayaUniversity of Illinois Chicago, College of Medicine, Biochemistry and Molecular Genetics.
Constantinos ChronisUniversity of Illinois Chicago, College of Medicine, Biochemistry and Molecular Genetics.
Thomas CundariUniversity of North Texas, Department of Chemistry.
Sushma SappaUniversity of Pittsburgh, Department of Chemistry.
Kabirul IslamUniversity of Pittsburgh.
Qingrong ChenNational Cancer Institute, Center for Biomedical Informatics and Information Technology.
Daoud MeerzamanNational Cancer Institute, Center for Biomedical Informatics and Information Technology.
Michael SierkNational Cancer Institute, Center for Biomedical Informatics and Information Technology.
University of Illinois Urbana-Champaign · USStanford University · USUniversity of Pittsburgh · USHouston Methodist · USNational Institutes of Health · USNorthwestern University · PHOllscoil na Gaillimhe – University of Galway · IEUniversity of Arizona · USUniversity of Illinois Chicago · USUniversity of North Texas · US
Funding
Uranium as an Environmental Risk Factor for Cancer Among the NavajoU54CA143924 · NCI · UNIVERSITY OF ARIZONA · PI Melissa Marie Herbst-Kralovetz, JUANITA L. MERCHANT · 2009 to 2026
$26.7MCoboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7MMeasuring and Modulating Oxidative DNA Damage Surveillance PathwaysR01CA217809 · NCI · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2017 to 2024
$3.7MDual targeting of PI3K and NOS pathways in Metaplastic BreastCancer (MBC)R01CA284315 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI JENNY C-N CHANG · 2023 to 2026
$2.6MA phase II multi-center trial evaluating dual targeting of the PI3K/AKT and NOS pathways for treating metaplastic breast cancer (MpBC)U01CA268813 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI JENNY C-N CHANG, FUNDA MERIC-BERNSTAM · 2022 to 2026
$2.0MCrosslinking-Assisted Substrate Identification for Lysine DemethylasesR01GM130752 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ISLAM, KABIRUL · 2020 to 2023
$1.2MNCI NIH HHS R01 CA217809NCI NIH HHS R01 CA284315NCI NIH HHS U01 CA268813NCI NIH HHS U54 CA143924NIGMS NIH HHS R01 GM111097NIGMS NIH HHS R01 GM130752
6 · The paper itselfAbstract
DNA methylation at cytosine bases of eukaryotic DNA (5-methylcytosine, 5mC) is a heritable epigenetic mark that can regulate gene expression in health and disease. Enzymes that metabolize 5mC have been well-characterized, yet the discovery of endogenously produced signaling molecules that regulate DNA methyl-modifying machinery have not been described. Herein, we report that the free radical signaling molecule nitric oxide (NO) can directly inhibit the Fe(II)/2-OG-dependent DNA demethylases ten-eleven translocation (TET) and human AlkB homolog 2 (ALKBH2). Physiologic NO concentrations reversibly inhibited TET and ALKBH2 demethylase activity by binding to the mononuclear non-heme iron atom which formed a dinitrosyliron complex (DNIC) preventing cosubstrates (2-OG and O
Identifiers
PMID38645113
PMCPMC11030528
OpenAlexW4393852934
What Socratic holds
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