Evidence map›Paper›PMID 38645166›Full record

ArticlebioRxiv : the preprint server for biology2024

IAPP Marks Mono-hormonal Stem-cell Derived β Cells that Maintain Stable Insulin Production

Jeffrey C Davis, Maria Ryaboshapkina, Jennifer H Kenty, Pinar Ö Eser, Suraj Menon, Björn Tyrberg, Douglas A Melton

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Jeffrey C DavisDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Boston MA 02138, United States of America.ORCID 0000-0003-0418-9106
Maria RyaboshapkinaTranslational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.ORCID 0000-0003-1385-8869
Jennifer H KentyDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Boston MA 02138, United States of America.
Pinar Ö EserHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1555-4981
Suraj MenonRDI Operations, Granta Park, AstraZeneca, Cambridge CB21 6GP, UK.
Björn TyrbergGlobal Insights, Analytics & Commercial Excellence, BioPharmaceuticals Business Unit, AstraZeneca, Gothenburg, Sweden.
Douglas A MeltonDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Boston MA 02138, United States of America.ORCID 0000-0002-4203-4415
Harvard Stem Cell Institute · USAstraZeneca (Brazil) · BRAstraZeneca (Sweden) · SEAstraZeneca (United Kingdom) · GBHarvard University · US

Funding

Biomarkers for Diabetes Using Stem Cell-Derived Beta CellsUC4DK104159 · NIDDK · HARVARD UNIVERSITY · PI MELTON, DOUGLAS A · 2014 to 2014
$1.6M
NIDDK NIH HHS UC4 DK104159
6 · The paper itself

Abstract

Islet transplantation for treatment of diabetes is limited by availability of donor islets and requirements for immunosuppression. Stem cell-derived islets might circumvent these issues. SC-islets effectively control glucose metabolism post transplantation, but do not yet achieve full function

Indexed as

in vitro differentiationin vivo maturationIslet Amyloid Polypeptide (IAPP)SC-isletsSC-β cells

Identifiers

PMID38645166
PMCPMC11030367
OpenAlexW4394720174

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.