Evidence map›Paper›PMID 38645427›Full record

ReviewFrontiers in endocrinology2024

Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications.

Dong-Rong Yang, Meng-Yan Wang, Cheng-Lin Zhang, Yu Wang

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07560800 (Effect of Beetroot Juice on Cardiovascular and Autonomic Responses During and After Exercise in Adults With Type 2 Diabetes), which is not on this map. Cited by 164 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 4 pooled it
39.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07560800 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Beetroot Juice on Cardiovascular and Autonomic Responses During and After Exercise in Adults With Type 2 Diabetes

TypeinterventionalSponsorOxford Brookes UniversityRan2026 to 2026Enrolled20ConditionsType 2 Diabetes Mellitus, Hypertension, Autonomic Nervous System DiseasesArmsBeetroot juice, Nitrate-depleted Beetroot Juice Placebo
3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 4 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dong-Rong YangDepartment of Endocrinology and Metabolism, Shenzhen University General Hospital, Shenzhen, Guangdong, China.
Meng-Yan WangDepartment of Pathophysiology, Shenzhen University Medical School, Shenzhen, Guangdong, China.
Cheng-Lin ZhangDepartment of Pathophysiology, Shenzhen University Medical School, Shenzhen, Guangdong, China.
Yu WangDepartment of Endocrinology and Metabolism, Shenzhen University General Hospital, Shenzhen, Guangdong, China.
Shenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic vascular complications are prevalent and severe among diabetic patients, profoundly affecting both their quality of life and long-term prospects. These complications can be classified into macrovascular and microvascular complications. Under the impact of risk factors such as elevated blood glucose, blood pressure, and cholesterol lipids, the vascular endothelium undergoes endothelial dysfunction, characterized by increased inflammation and oxidative stress, decreased NO biosynthesis, endothelial-mesenchymal transition, senescence, and even cell death. These processes will ultimately lead to macrovascular and microvascular diseases, with macrovascular diseases mainly characterized by atherosclerosis (AS) and microvascular diseases mainly characterized by thickening of the basement membrane. It further indicates a primary contributor to the elevated morbidity and mortality observed in individuals with diabetes. In this review, we will delve into the intricate mechanisms that drive endothelial dysfunction during diabetes progression and its associated vascular complications. Furthermore, we will outline various pharmacotherapies targeting diabetic endothelial dysfunction in the hope of accelerating effective therapeutic drug discovery for early control of diabetes and its vascular complications.

Indexed as

Diabetic AngiopathiesEndothelium, VascularAnimalsHumansOxidative Stressatheroscleroticdiabetesendothelial dysfunctiontherapiesvascular diseases

Identifiers

PMID38645427
PMCPMC11026568
OpenAlexW4393987103

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.