Evidence map›Paper›PMID 38646635›Full record

ArticleFrontiers in microbiology2024

A novel front in sustainable microbial management: computational analysis of curcumin and mangiferin's synergistic action against

Kahkashan Perveen, Najat A Bukhari, Najla A Alshaikh, Suresh Babu Kondaveeti, Jamilah A Alsulami, Sandip Debnath, Vinoth Kumarasamy

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Kahkashan PerveenDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Najat A BukhariDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Najla A AlshaikhDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Suresh Babu KondaveetiDepartment of Biochemistry, Symbiosis Medical College for Women, Symbiosis International (Deemed University), Pune, India.
Jamilah A AlsulamiMicrobiology Department, Howard University, Washington, DC, United States.
Sandip DebnathDepartment of Genetics and Plant Breeding, Institute of Agriculture, Visva-Bharati University, Sriniketan, West Bengal, India.
Vinoth KumarasamyDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
King Saud University · SAHoward University · USNational University of Malaysia · MYSymbiosis International University · INVisva-Bharati University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Microorganisms are crucial in our ecosystem, offering diverse functions and adaptability. The UNGA Science Summit has underscored the importance of understanding microbes in alignment with the UN Sustainable Development Goals. Methods: Employing high-throughput screening, we identified potential binding sites on Findings: Results of Molecular docking indicated binding energies of -8.45 kcal/mol for mangiferin, -7.68 kcal/mol for curcumin, and a notably higher binding energy of -19.47 kcal/mol for the combination of mangiferin and curcumin with CapD protein. Molecular dynamics simulations further validated these interactions, demonstrating increased stability and structural changes in the bacterium. Conclusion: This study highlights the effectiveness of natural compounds like curcumin and mangiferin in microbial management, especially against challenging pathogens like

Indexed as

antibioticsBacillus anthracisbiotherapeuticscurcuminmangiferinmolecular dockingsynthetic biology

Identifiers

PMID38646635
PMCPMC11026599
OpenAlexW4393987135

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.