Evidence map›Paper›PMID 38646784›Full record

ArticleAmerican journal of physiology. Cell physiology2024

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF.

Dan J K Yombo, Sudhir Ghandikota, Chanukya P Vemulapalli, Priyanka Singh, Anil G Jegga, William D Hardie, Satish K Madala

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dan J K YomboDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.ORCID 0000-0002-1469-503X
Sudhir GhandikotaDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States.
Chanukya P VemulapalliDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.
Priyanka SinghDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.ORCID 0000-0002-9569-787X
Anil G JeggaDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States.ORCID 0000-0002-4881-7752
William D HardieDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Satish K MadalaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.ORCID 0000-0002-6042-5321
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · US

Funding

WT1 REGULATION OF PULMONARY FIBROSISR01HL134801 · NHLBI · UNIVERSITY OF CINCINNATI · PI MADALA, SATISH K · 2017 to 2025
$3.9M
Sox9 Regulation of Fibroblast Activation and Pulmonary FibrosisR01HL157176 · NHLBI · UNIVERSITY OF CINCINNATI · PI MADALA, SATISH K · 2021 to 2025
$2.5M
NHLBI NIH HHS R01 HL134801NHLBI NIH HHS R01 HL157176
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is marked by the activation of fibroblasts, leading to excessive production and deposition of extracellular matrix (ECM) within the lung parenchyma. Despite the pivotal role of ECM overexpression in IPF, potential negative regulators of ECM production in fibroblasts have yet to be identified. Semaphorin class 3B (SEMA3B), a secreted protein highly expressed in lung tissues, has established roles in axonal guidance and tumor suppression. However, the role of SEMA3B in ECM production by fibroblasts in the pathogenesis of IPF remains unexplored. Here, we show the downregulation of

Indexed as

Extracellular Matrix ProteinsFibroblastsIdiopathic Pulmonary FibrosisLungNeuropilin-1SemaphorinsTransforming Growth Factor betaAnimalsCells, CulturedExtracellular MatrixFemaleHumansMaleMembrane GlycoproteinsMiceMice, Inbred C57BLExtracellular Matrix ProteinsMembrane GlycoproteinsNeuropilin-1NRP1 protein, humanSEMA3B protein, humanSema3b protein, mouseSemaphorinsTransforming Growth Factor betaextracellular matrixfibroblastspulmonary fibrosisSEMA3BTGFβ

Identifiers

PMID38646784
PMCPMC11371361
OpenAlexW4395009529

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.