Evidence map›Paper›PMID 38647657›Full record

ArticlePediatric cardiology2025

Fetal Echocardiographic Evaluation of Tricuspid Valve and Right Ventricular Function Including Global Longitudinal Strain in Hypoplastic Left Heart Syndrome and Association with Postnatal Outcomes.

Benjamin Ittleman, Sarah Lowenstein, Lindsay A Edwards, Elizabeth Caris, Aarti Bhat, Jeffrey Conwell, Mark Lewin, Bhawna Arya

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Benjamin IttlemanArkansas Children's Hospital, University of Arkansas Medical Sciences, Little Rock, AR, USA. Bittleman@uams.edu.
Sarah LowensteinMetropolitan Pediatrics, Portland, OR, USA.
Lindsay A EdwardsDepartment of Pediatrics, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Elizabeth CarisUniversity of Pittsburgh School of Medicine, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Aarti BhatSeattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA.
Jeffrey ConwellSeattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA.
Mark LewinSeattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA.
Bhawna AryaSeattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA.
Seattle Children's Hospital · USUniversity of Washington · USArkansas Children's Hospital · USDuke University · USUniversity of Pittsburgh Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite significant advancements in the care of patients with hypoplastic left heart syndrome (HLHS) morbidity and mortality remain high. Postnatal right ventricular dysfunction and tricuspid regurgitation (TR) are associated with worse outcomes in HLHS. We aim to determine if right ventricle functional parameters and TR on fetal echocardiogram are associated with postnatal outcomes in HLHS patients. Retrospective review was performed on all fetuses with HLHS from 2014 to 2022 at our institution. Initial and follow up fetal echocardiogram measurements of right ventricular myocardial performance index (MPI), fractional area change (FAC) and global longitudinal strain (GLS) were retrospectively measured. The presence and severity of TR was recorded from the fetal echocardiogram reports. Postnatal outcomes including transplant-free survival, hospital length of stay > 30 days after initial palliation and need for bidirectional Glenn at < 4 months were reviewed. Forty-three subjects met inclusion criteria. Mean gestational age at presentation was 26.1 ± 5.9 weeks. Nine subjects died and 3 required heart transplantation. Initial fetal echocardiogram MPI was significantly lower (better) (0.36 ± 0.06 vs 0.44 ± 0.11; p =  < 0.001) and FAC was significantly higher (better) (45 ± 6% vs 40 ± 8%; p = 0.035) in transplant-free survivors. Fetal right ventricular GLS and presence of mild TR were not associated with postnatal outcome. In fetuses with HLHS, abnormal MPI and right ventricular FAC are associated with decreased transplant-free survival. There was no observed association between GLS and postnatal outcomes. To our knowledge this is the first study examining fetal right ventricular function and GLS in HLHS patients and its link to postnatal outcomes.

Indexed as

EchocardiographyFetal HeartHeart VentriclesHypoplastic Left Heart SyndromeTricuspid ValveTricuspid Valve InsufficiencyUltrasonography, PrenatalVentricular Dysfunction, RightVentricular Function, RightFemaleGestational AgeGlobal Longitudinal StrainHumansInfant, NewbornMalePregnancyFetal echocardiogramFractional area changeHypoplastic left heart syndromeMyocardial performance index

Identifiers

PMID38647657
OpenAlexW4395010999

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.