Evidence map›Paper›PMID 38647679›Full record

ArticleBioprocess and biosystems engineering2024

Ultrasonic synthesis of green lipid nanocarriers loaded with Scutellaria barbata extract: a sustainable approach for enhanced anticancer and antibacterial therapy.

Raghu Jetti, Maritza Lucia Vaca Cárdenas, Haider Falih Shamikh Al-Saedi, Shaymaa Abed Hussein, Hussam Abdali Abdulridui, Salah Hassan Zain Al-Abdeen, Usama Kadem Radi, Adnan Hashim Abdulkadhim, Sahar Balkit Hussein, Ahmed Alawadi and 1 more

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Article in Bioprocess and biosystems engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raghu JettiDepartment of Basic Medical Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Maritza Lucia Vaca CárdenasFacultad de Ciencias Pecuarias, Escuela Superior Politécnica de Chimborazo (ESPOCH), Panamericana Sur Km 1½, Riobamba, 060155, Ecuador.
Haider Falih Shamikh Al-SaediFaculty of Pharmacy, Department of Pharmaceutics, University of Al-Ameed, Karbala, Iraq.
Shaymaa Abed HusseinDepartment of Dentistry, Al-Manara College for Medical Sciences, Maysan, Iraq.
Hussam Abdali AbdulriduiDepartment of Medical Laboratories, Technology, Al-Hadi University College, Baghdad, Iraq.
Salah Hassan Zain Al-AbdeenDepartment of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq.
Usama Kadem RadiCollege of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
Adnan Hashim AbdulkadhimDepartment of Computer Engineering, Technical Engineering College, Al-Ayen University, Dhi Qar, Iraq.
Sahar Balkit HusseinDepartment of Pharmacy, Al-Rafidain University College, Bagdad, Iraq.
Ahmed AlawadiCollege of Technical Engineering, The Islamic University, Najaf, Iraq. elwadiamed@gmail.com.
Ali AlsalamyCollege of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, 66002, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasonic manufacturing has emerged as a promising eco-friendly approach to synthesize lipid-based nanocarriers for targeted drug delivery. This study presents the novel ultrasonic preparation of lipid nanocarriers loaded with Scutellaria barbata extract, repurposed for anticancer and antibacterial use. High-frequency ultrasonic waves enabled the precise self-assembly of DSPE-PEG, Span 40, and cholesterol to form nanocarriers encapsulating the therapeutic extract without the use of toxic solvents, exemplifying green nanotechnology. Leveraging the inherent anticancer and antibacterial properties of Scutellaria barbata, the study demonstrates that lipid encapsulation enhances the bioavailability and controlled release of the extract, which is vital for its therapeutic efficacy. Dynamic light scattering and transmission electron microscopy analyses confirmed the increase in size and successful encapsulation post-loading, along with an augmented negative zeta potential indicating enhanced stability. A high encapsulation efficiency of 91.93% was achieved, and in vitro assays revealed the loaded nanocarriers' optimized release kinetics and improved antimicrobial potency against Pseudomonas aeruginosa, compared to the free extract. The combination of ultrasonic synthesis and Scutellaria barbata in an eco-friendly manufacturing process not only advances green nanotechnology but also contributes to sustainable practices in pharmaceutical manufacturing. The data suggest that this innovative nanocarrier system could provide a robust platform for the development of nanotechnology-based therapeutics, enhancing drug delivery efficacy while aligning with environmental sustainability.

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsPlant ExtractsScutellariaDrug CarriersGreen Chemistry TechnologyHumansLipidsNanoparticlesPseudomonas aeruginosaUltrasonicsUltrasonic WavesAnti-Bacterial AgentsAntineoplastic AgentsDrug CarriersLipidsPlant ExtractsScutellaria barbata extractDrug deliveryEco-friendly manufacturingGreen nanotechnologyLipid nanocarriersScutellaria barbataUltrasonic synthesis

Identifiers

PMID38647679

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.