Evidence map›Paper›PMID 38649724›Full record

ArticlePediatric research2024

Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty.

Peng Xue, Jianfei Lin, Jingyi Tang, Yao Chen, Tingting Yu, Chang Chen, Huijun Kong, Cuilan Lin, Shijian Liu

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Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Peng XueSchool of Public Health, Shanghai Jiao Tong University, Shanghai, China.
Jianfei LinDepartment of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jingyi TangSchool of Public Health, Shanghai Jiao Tong University, Shanghai, China.
Yao ChenDepartment of Endocrinology and Genetic Metabolism, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Tingting YuSchool of Public Health, Shanghai Jiao Tong University, Shanghai, China.
Chang ChenSchool of Public Health, Shanghai Jiao Tong University, Shanghai, China.
Huijun KongDepartment of Pediatrics, Qufu People's Hospital, Qufu, Shandong, China.
Cuilan LinBoai Hospital of Zhongshan, Southern Medical University, Zhongshan, Guangdong, China.
Shijian LiuSchool of Public Health, Shanghai Jiao Tong University, Shanghai, China. liushijian@scmc.com.cn.ORCID 0000-0002-7050-463X
Shanghai Jiao Tong University · CNBoai Hospital of Zhongshan · CNQufu Normal University · CN

Funding

National Natural Science Foundation of China
6 · The paper itself

Abstract

backgroundObesity is an important cause for the precocious or early puberty. However, the association between obesity-related loci and the risk of precocious puberty as well as the effect of gene-environment interaction are unclear, especially in the Chinese children population.

methodsThis was a case-control study using baseline data from two cohorts and hospital cases in China. 15 SNPs loci and several environmental factors were included in the analysis of 1201 participants. Chi-square test and logistic regression were used to analyze the association between SNPs and precocious puberty. Additionally, exploratory factor analysis was conducted on 13 environmental variables, and then to explore their interaction with genes on precocious puberty.

resultsThe effect allele C of rs571312, and G of rs12970134 MC4R were associated with precocious puberty in girls with obesity. Regarding the gene-environment interaction, we found that when girls were in the high socioeconomic status, the rs571312 (OR: 3.996; 95% CI: 1.694-9.423) and rs12970134 (OR: 3.529; 95% CI: 1.452-8.573) risk genotypes had a greater effect on precocious puberty.

conclusionsThe obesity risk gene polymorphisms MC4R rs571312 and rs12970134 were associated with precocious puberty in Chinese girls with obesity, and girls with risk genotypes and high socioeconomic status should be given extra attention. IMPACT: This is the first study that identified the association between rs571312 and rs12970134 of MC4R gene and precocious puberty in Chinese children. We found that when girls were in the high socioeconomic status, the risk genotypes of rs571312 and rs12970134 had a greater effect on precocious puberty. The results of this study have great public health implications. It is recommended that girls who are in high socioeconomic status and have a high genetic risk for early sexual maturity should closely monitor their pubertal development and consider early intervention strategies.

Indexed as

Gene-Environment InteractionMenarchePolymorphism, Single NucleotidePuberty, PrecociousReceptor, Melanocortin, Type 4AllelesCase-Control StudiesChildChinaEast Asian PeopleFemaleGenetic Predisposition to DiseaseGenotypeHumansObesityPediatric ObesityMC4R protein, humanReceptor, Melanocortin, Type 4

Identifiers

PMID38649724
OpenAlexW4395003825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.