ArticleFrontiers in aging neuroscience2024
Association between Life's Essential 8 and cognitive function: insights from NHANES 2011-2014.
Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Association of central adiposity indices with cognitive impairment in elderly populations: Development and validation of a risk prediction nomogram using NHANES and CHARLS cohorts.Journal of Alzheimer's disease : JAD · 2026Article
- Gender-dependent association between cardiovascular health and cognitive function in chinese older adults: a community based cohort study.Cerebral circulation - cognition and behavior · 2026Article
- Novel associations between life's crucial 9 components and cognitive health in a National Cohort of Older Americans.Medicine · 2025Article
- Association between the American heart association's life's essential 8 score and cognitive function: a cross-sectional NHANES study.BMC geriatrics · 2025Article
- Healthy Cardiovascular Status Attenuates the Detrimental Association Between Osteosarcopenic Adiposity and Alzheimer's Disease-Related Dementia: A UK Biobank Cohort Study.Journal of the American Heart Association · 2025Article
- Article
- Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Adherence to Life's Essential 8 enhances gut microbiota diversity and cognitive performance.Frontiers in microbiomes · 2025Article
- Association between Life's Essential 8 and frailty among the United States older people.Frontiers in public health · 2025Article
- Association between cardiovascular health assessed by life's essential 8 and hyperuricemia in U.S. adults: the NHANES 2009-2020.Frontiers in endocrinology · 2024Article
- A glimpse into the future: revealing the key factors for survival in cognitively impaired patients.Frontiers in aging neuroscience · 2024Article
- Does Cardiovascular Health Influence the Well-Being of People Living in Rural Areas: Findings From a 20-Year Study in US Adults.Sage open agingArticle
- Life's Essential 8™ and incident dementia in an urban cohort: Findings from the Northern Manhattan Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Life's Essential 8 (LE8) is prompted by the American Heart Association (AHA) to assess cardiovascular health. The association between LE8 and cognitive function in America is unknown. Our study was to investigate the association of LE8 with cognitive function in general adults. Materials and methods: A total of 2,301 participants were enrolled in the National Health and Nutrition Examination Surveys (NHANES). LE8 scores (range 0-100) were obtained from measurements based on American Heart Association definitions, divided into health behavior and health factor scores. Cognitive function was assessed by three tests including the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Animal fluency test (AFT), and Digit Symbol Substitution test (DSST). The multivariable linear regression analysis explored the associations between LE8 and cognitive function. Smooth curve fitting was explored using restricted cubic splines. The inflection point was determined by the two-piecewise linear regression. Results: In the multivariable linear regression model with full adjustment for confounding variables, AFT scores were 1.2 points higher in participants with LE8 scores >80 than in those with LE8 scores <50 (high LE8 score group: Conclusion: Our study highlighted a positive association between Life's Essential 8 and cognitive function in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.