ArticleBMC biology2024
Hypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals.
Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 16 citations in OpenAlex.
- Dehydration promotes intracellular lipid synthesis and accumulation.Nature communications · 2026Article
- Pygmy sperm whale multi-omics data reveal hypoxia adaptations in deep-diving cetaceans.BMC biology · 2025Article
- The molecular evolutionary basis of species formation revisited.Trends in genetics : TIG · 2025Review
- Prolonged fasting and glucocorticoid exposure drive dynamic DNA methylation in northern elephant seals.The Journal of experimental biology · 2025Article
- Hypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals.BMC biology · 2024Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundElephant seals exhibit extreme hypoxemic tolerance derived from repetitive hypoxia/reoxygenation episodes they experience during diving bouts. Real-time assessment of the molecular changes underlying protection against hypoxic injury in seals remains restricted by their at-sea inaccessibility. Hence, we developed a proliferative arterial endothelial cell culture model from elephant seals and used RNA-seq, functional assays, and confocal microscopy to assess the molecular response to prolonged hypoxia.
resultsSeal and human endothelial cells exposed to 1% O
conclusionsWe found that the glutathione antioxidant system is upregulated in seal endothelial cells during hypoxia, while this system remains static in comparable human cells. Furthermore, we found that in contrast to human cells, hypoxia exposure rapidly activates HIF-1 in seal cells, but this response is decoupled from the canonical angiogenesis pathway. These results highlight the unique mechanisms that confer extraordinary tolerance to limited oxygen availability in a champion diving mammal.
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