Evidence map›Paper›PMID 38654824›Full record

ArticlebioRxiv : the preprint server for biology2024

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.

Radhika Joshi, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szabo

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Radhika JoshiDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, USA.
Veronika BrezaniDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, USA.
Gabrielle M MeyDepartment of Opthalmology and Visual Sciences, Kellogg Eye Center Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA.
Sergi Guixé-MuntetLiver Vascular Biology, IDIBAPS Biomedical Research Institute- CIBEREHD, Barcelona, Spain.
Marti Ortega-RiberaDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, USA.
Yuan ZhuangDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, USA.
Adam ZivnyDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, USA.
Sebastian WerneburgDepartment of Opthalmology and Visual Sciences, Kellogg Eye Center Michigan Neuroscience Institute, University of Michigan, Ann Arbor, USA.
Jordi Gracia-SanchoLiver Vascular Biology, IDIBAPS Biomedical Research Institute- CIBEREHD, Barcelona, Spain.
Gyongyi SzaboDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, USA.
Beth Israel Deaconess Medical Center · USUniversity of Michigan · USInstitut d'Investigacions Biomèdiques de Barcelona · ESUniversity of Bern · CH

Funding

MicroRNAs in Alcoholic Liver Disease Administrative SupplementR01AA020744 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 2011 to 2023
$5.3M
TLR4 Signaling in alcoholic liver diseaseR01AA017729 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 2009 to 2021
$4.3M
Inflammasome activation in modulation of Alzheimer’s Disease by alcohol Administrative SupplementR01AG072899 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GOLENBOCK, DOUGLAS T, SZABO, GYONGYI · 2020 to 2025
$2.4M
NIAAA NIH HHS R01 AA017729NIAAA NIH HHS R01 AA020744NIA NIH HHS R01 AG072899
6 · The paper itself

Abstract

The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF3 deficiency delays TLR4-mediated signaling in microglia and attenuates the hallmark features of LPS-induced inflammation such as cytokine release, microglial reactivity, astrocyte activation, myeloid cell infiltration, and inflammasome activation. Moreover, expression of a constitutively active IRF3 (S388D/S390D:IRF3-2D) in microglia induces a transcriptional program reminiscent of the Activated Response Microglia and the expression of genes associated with Alzheimer's Disease, notably

Indexed as

Activated response microgliaAlzheimer’s diseaseARMDAMInterferon response microgliaIRF3IRMNeuroinflammationType 1 interferonZBP1

Identifiers

PMID38654824
PMCPMC11037866
OpenAlexW4392748728

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.