Evidence map›Paper›PMID 38655258›Full record

Trial reportFrontiers in immunology2024

Effect of high-dose

Mohammad Reza Aghasadeghi, Mohammad Ali Zaheri Birgani, Saeedreza Jamalimoghadamsiyahkali, Hadiseh Hosamirudsari, Ali Moradi, Majid Jafari-Sabet, Nooshin Sadigh, Pooneh Rahimi, Rezvan Tavakoli, Mojtaba Hamidi-Fard and 16 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Commentary: Effect of high-doseFrontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 6 institutions in 3 countries.

Mohammad Reza Aghasadeghi *Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
Mohammad Ali Zaheri Birgani *Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
Saeedreza JamalimoghadamsiyahkaliZiaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hadiseh HosamirudsariDepartment of Infectious Disease, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ali MoradiIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Majid Jafari-SabetDepartment of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Nooshin SadighIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Pooneh RahimiHepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
Rezvan TavakoliHepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
Mojtaba Hamidi-FardHepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
Golnaz BahramaliHepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
Zohal ParmoonIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Sina Arjmand HashjinHepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
Ghasem MirzajaniLaboratory Department, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Reza KouhkheilEmergency Department, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Somayeh RoshangaranIntensive Care Unit, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Samineh KhalafIntensive Care Unit, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Khademi NadoushanIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Ghazaleh Gholamiyan Yousef AbadIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Nima ShahryarpourEmergency Department, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad IzadiIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Abolfazl ZendedelDepartment of Internal Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Shayesteh JahanfarDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, United States.
Omid DadrasIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
SeyedAhmad SeyedAlinaghiIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Daniel HackettPhysical Activity, Lifestyle, Ageing and Wellbeing Faculty Research Group, School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Tehran University of Medical Sciences · IRIranian Institute for Health Sciences Research · IRPasteur Institute of Iran · IRIran University of Medical Sciences · IRThe University of Sydney · AUTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Study Design: We conducted a randomized, controlled, open-label trial involving 189 patients with COVID-19 who were randomly assigned in a 1:1 ratio to an experimental group that received 15.2g of Results: Within seven days, there were no deaths in the Conclusion: High-dose Clinical Trial Registration: https://irct.ir/trial/54375, Iranian Registry of Clinical Trials number (IRCT20210216050373N1).

Indexed as

COVID-19COVID-19 Drug TreatmentDietary SupplementsSARS-CoV-2SpirulinaAdultAgedCytokinesFemaleHospitalizationHumansIntensive Care UnitsMaleMiddle AgedTreatment OutcomeCytokinesCOVID-19hospital dischargeimmune mediatorsintensive care unit (ICU) & non-ICUmortalitySpirulina platensis

Identifiers

PMID38655258
PMCPMC11036872
OpenAlexW4394573793

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.