Evidence map›Paper›PMID 38656363›Full record

ArticleJournal of cancer research and clinical oncology2024

UBE2L3 expression in human gastric cancer and its clinical significance.

Xiaoxia Zhang, Yujie Wei, Fanqi Wu, Mei Li, Cong Han, Chengdong Huo, Zhi Li, Futian Tang, Wenting He, Yang Zhao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. International journal of biological sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaoxia ZhangDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Yujie WeiDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Fanqi WuDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Mei LiDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Cong HanDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Chengdong HuoDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Zhi LiDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Futian TangDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Wenting HeDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China.
Yang ZhaoDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China. ery_zhaoyang@lzu.edu.cn.
Yumin LiDepartment of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China. liym@lzu.edu.cn.
Lanzhou University Second Hospital · CNLanzhou University · CN

Funding

Fundamental Research Funds for the Central Universities of Lanzhou University lzujbky-2022-sp08Gansu key research and development program 23YFFA0037Major Science and Technology Project of Gansu Province 20ZD7FA003Major Science and Technology Project of Gansu Province 22JR9KA002Major Science and Technology Project of Gansu Province 22ZD6FA050Medical Innovation and Development Project of Lanzhou University lzuyxcx-2022-141Medical Innovation and Development Project of Lanzhou University lzuyxcx-2022-154Natural Science Foundation of Gansu Province 21JR1RA135Natural Science Foundation of Gansu Province 22JR5RA983Natural Science Foundation of Gansu Province 23JRRA1001Project of Gansu Provincial Department of Education 2021jyjbgs-02Project of Gansu Provincial Development and Reform Commission 2020-2022Scientific research training program for Cuiying students in the Second Hospital of Lanzhou University CYXZ2023-47
6 · The paper itself

Abstract

purposeGastric cancer (GC) is prevalent as one of the most common malignant tumors globally, with a particularly high incidence in China. The role of UBE2L3 in the initiation and progression of various cancers has been well documented, but its specific significance in GC is not yet fully elucidated. The objective of this study is to examine the expression and importance of UBE2L3 in human gastric cancer tissues.

methodsImmunohistochemical staining and survival analysis were conducted on 125 cases of GC. Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) were employed to assess the expression of UBE2L3 in GC cell lines. Cell lines with UBE2L3 knockdown and overexpression were cultured through lentivirus transfection and subsequently assessed using Western blot analysis. The involvement of UBE2L3 in the proliferation, invasion, and apoptosis of GC cells was confirmed through in vitro experiments, and its capacity to facilitate tumor growth was also validated in in vivo studies.

resultsThe up-regulation of UBE2L3 expression was observed in GC, and its high expression was found to be significantly associated with the degree of differentiation (χ

conclusionsThe findings of our study demonstrate the significant involvement of UBE2L3 in the pathogenesis and advancement of gastric cancer, suggesting its potential as a therapeutic target.

Indexed as

ApoptosisCell ProliferationStomach NeoplasmsUbiquitin-Conjugating EnzymesAdultAnimalsBiomarkers, TumorCell Line, TumorClinical RelevanceFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudeBiomarkers, TumorUBE2L3 protein, humanUbiquitin-Conjugating EnzymesGastric cancerOncogenesUBE2L3Ubiquitin-conjugating enzyme E2

Identifiers

PMID38656363
PMCPMC11043109
OpenAlexW4395074140

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.