Evidence map›Paper›PMID 38659736›Full record

ArticlebioRxiv : the preprint server for biology2024

Multicomponent depolymerization of actin filament pointed ends by cofilin and cyclase-associated protein depends upon filament age.

Ekram M Towsif, Blake Andrew Miller, Heidi Ulrichs, Shashank Shekhar

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ekram M TowsifDepartments of Physics, Cell biology and Biochemistry, Emory University, Atlanta, GA 30322.
Blake Andrew MillerDepartments of Physics, Cell biology and Biochemistry, Emory University, Atlanta, GA 30322.
Heidi UlrichsDepartments of Physics, Cell biology and Biochemistry, Emory University, Atlanta, GA 30322.
Shashank ShekharDepartments of Physics, Cell biology and Biochemistry, Emory University, Atlanta, GA 30322.ORCID 0000-0003-1494-0151
Emory University · US

Funding

MULTICOMPONENT MECHANOCHEMICAL REGULATION OF ACTIN FILAMENT END DYNAMICSR35GM143050 · NIGMS · EMORY UNIVERSITY · PI Shashank Shekhar · 2021 to 2026
$2.7M
NIGMS NIH HHS R35 GM143050
6 · The paper itself

Abstract

Intracellular actin networks assemble through the addition of ATP-actin subunits at the growing barbed ends of actin filaments. This is followed by "aging" of the filament via ATP hydrolysis and subsequent phosphate release. Aged ADP-actin subunits thus "treadmill" through the filament before being released back into the cytoplasmic monomer pool as a result of depolymerization at filament pointed ends. The necessity for aging before filament disassembly is reinforced by preferential binding of cofilin to aged ADP-actin subunits over newly-assembled ADP-P

Indexed as

actin depolymerizationCofilincyclase-associated protein (CAP)

Identifiers

PMID38659736
PMCPMC11042253
OpenAlexW4394853037

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.