Evidence map›Paper›PMID 38660803›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2024

Effects of a Global

Ashley Soucy, Christian Potts, Abigail Kaija, Anne Harrington, Marissa McGilvrey, George L Sutphin, Ron Korstanje, Benjamin Tero, Jacob Seeker, Ilka Pinz and 3 more

Open access · greenAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Exosome trafficking is a key regulator of adipocyte thermogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Rab27: Molecular switch of tumor exosome secretion (Review).International journal of molecular medicine · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Ashley SoucyMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Christian PottsMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).ORCID 0009-0007-7794-7840
Abigail KaijaMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).ORCID 0009-0003-0724-7751
Anne HarringtonMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Marissa McGilvreyMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).ORCID 0000-0003-1707-8886
George L SutphinThe Jackson Laboratory, Bar Harbor, ME (G.L.S., R.K.).ORCID 0000-0002-3659-4678
Ron KorstanjeGraduate School of Biomedical Science and Engineering, University of Maine, Orono (A.S., M.M., R.K., I.P., C.V., L.L.).ORCID 0000-0002-2808-1610
Benjamin TeroMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Jacob SeekerMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).ORCID 0009-0003-0622-6799
Ilka PinzMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Calvin VaryMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Larisa RyzhovaMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Lucy LiawMaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).ORCID 0000-0003-3341-0156
MaineHealth · USJackson Laboratory · USUniversity of Arizona · US

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Susan L SANTANGELO · 2017 to 2026
$51.6M
The role of night shift work in metabolic disorders during and after pregnancyP20GM121301 · NIGMS · MAINEHEALTH · PI Lucy Liaw · 2017 to 2026
$25.1M
Translational CoreP30AG038070 · NIA · JACKSON LABORATORY · PI John Matthew Mahoney · 2010 to 2026
$19.3M
Regulation of arterial phenotype by perivascular adipose tissue in cardiometabolic diseaseR01HL141149 · NHLBI · MAINEHEALTH · PI LIAW, LUCY · 2018 to 2025
$4.3M
Transdisciplinary Predoctoral Training in Biomedical Science and EngineeringT32GM132006 · NIGMS · UNIVERSITY OF MAINE ORONO · PI GREGORY A. COX, Clarissa A Henry · 2019 to 2026
$2.0M
Sciex TripleTOF 6600+ system mass spectrometer and dedicated in-line EKSPERT nanoLC 425 liquid chromatographic systemS10OD028508 · OD · MAINEHEALTH · PI VARY, CALVIN PARDEE HULL · 2020 to 2020
$542k
NHLBI NIH HHS R01 HL141149NIA NIH HHS P30 AG038070NIGMS NIH HHS P20 GM121301NIGMS NIH HHS T32 GM132006NIGMS NIH HHS U54 GM115516NIH HHS S10 OD028508
6 · The paper itself

Abstract

backgroundRAB27A is a member of the RAS oncogene superfamily of GTPases and regulates cell secretory function. It, is expressed within blood vessels and perivascular adipose tissue. We hypothesized that loss of RAB27A would alter cardiovascular function.

methodsBody weight of

resultsGenome-wide association data linked rare human

conclusionsGlobal RAB27A loss impacted perivascular adipose tissue and thoracic aorta proteomic signatures, altered vasocontractile responses, and decreased left ventricular ejection fraction in mice.

Indexed as

Mice, Inbred C57BLMice, Knockoutrab27 GTP-Binding ProteinsAdipose TissueAge FactorsAnimalsAortaFemaleHumansMaleMicePhenotypeProteomicsSex FactorsVasoconstrictionVasodilationRab27a protein, mouserab27 GTP-Binding Proteinsadipocytesblood vesselscardiomyopathiesechocardiographylipidsmyographyproteomics

Identifiers

PMID38660803
PMCPMC11209784
OpenAlexW4395463697

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.