Evidence map›Paper›PMID 38664355›Full record

ArticleMolecular imaging and biology2024

Molecular Imaging of Fibroblast Activation in Rabbit Atherosclerotic Plaques: a Preclinical PET/CT Study.

Tianxiong Ji, Chunfang Zan, Lina Li, Jianbo Cao, Yao Su, Hongliang Wang, Zhifang Wu, Min-Fu Yang, Kefei Dou, Sijin Li

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Association of Atherosclerosis [Molecular imaging and biology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tianxiong Ji *Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, China.
Chunfang Zan *Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, China.
Lina LiDepartment of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Jianbo CaoDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, China.
Yao SuDepartment of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Hongliang WangDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, China.
Zhifang WuDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, China. wuzhifang01@163.com.
Min-Fu YangCollaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, 030001, China. minfuyang@126.com.
Kefei DouState Key Laboratory of Cardiovascular Disease, Beijing, 100037, China. drdoukefei@126.com.
Sijin LiDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, China. lisjnm123@163.com.ORCID 0000-0002-2010-3459
Shanxi Medical University · CNCapital Medical University · CNChinese Center For Disease Control and Prevention · CN

Funding

CAMS Innovation Fund for Medical Sciences 2021-I2M-1-008National Natural Science Foundation of China 81971655National Natural Science Foundation of China U22A6008Natural Science Foundation for Young Scientists of Shanxi Province 202303021212139the projects for Local Science and Technology Development Guided by the Central Committee of Shanxi Province YDZJSX2021B013
6 · The paper itself

Abstract

aimAtherosclerosis remains the pathological basis of myocardial infarction and ischemic stroke. Early and accurate identification of plauqes is crucial to improve clinical outcomes of atherosclerosis patients. Our study aims to evaluate the potential value of fibroblast activation protein inhibitor (FAPI)-04 PET/CT in identifying plaques via a preclinical rabbit model of atherosclerosis.

methodsNew Zealand white rabbits were fed high-fat diet (HFD), and randomly divided into the model group injured by the balloon, and the sham group only with incisions. Ultrasound was performed to detect plaques, and FAPI-avid was determined through Al

resultsThe rabbit carotid and abdominal atherosclerosis model was established. Al

conclusionsWe successfully achieve molecular imaging of fibroblast activation in atherosclerotic lesions of rabbits, suggesting Al

Indexed as

Molecular ImagingPlaque, AtheroscleroticPositron Emission Tomography Computed TomographyAnimalsDisease Models, AnimalEndopeptidasesFibroblast Activation Protein AlphaFibroblastsMaleMembrane ProteinsRabbitsTissue DistributionEndopeptidasesFibroblast Activation Protein AlphaMembrane ProteinsAtherosclerosisFibroblast activation proteinFibroblast activation protein inhibitorPET/CT imagingPlaque

Identifiers

PMID38664355
OpenAlexW4395447824

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.