Evidence map›Paper›PMID 38665263›Full record

ReviewFrontiers in endocrinology2024

Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose.

Silvia Martina Ferrari, Armando Patrizio, Valeria Mazzi, Francesca Ragusa, Chiara Botrini, Giusy Elia, Eugenia Balestri, Emilio Barozzi, Licia Rugani, Fabiana Bracchitta and 7 more

Open access · goldAbstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Silvia Martina Ferrari *Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Armando Patrizio *Department of Emergency Medicine, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Valeria MazziDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Francesca RagusaDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Chiara BotriniDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Giusy EliaDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Eugenia BalestriDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Emilio BarozziDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Licia RuganiDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Fabiana BracchittaDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Giulio StoppiniDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Giada FrenzilliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Enke BaldiniDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
Camilla ViriliDepartment of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.
Salvatore BenvengaDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Poupak FallahiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Alessandro AntonelliDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
University of Pisa · ITSapienza University of Rome · ITAzienda Ospedaliera Universitaria Pisana · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In hypothyroid patients needing large doses of levothyroxine (L-T4) (>1.7-2 μg/kg/day) to reach euthyroidism, lactose intolerance (LI) needs to be excluded, owing to the high prevalence in the population. If LI is present, a lactose-free diet decreases the rate of L-T4 malabsorption. However, an increased requirement of L-T4 is described in patients with LI, which can be beneficially treated using lactose-free L-T4 formulation. The lactose-free liquid L-T4 formulation is able to circumvent LI malabsorption leading to the normalization of thyroid-stimulating hormone (TSH) in patients with subclinical hypothyroidism and long-term stable TSH levels.

Indexed as

HypothyroidismLactose IntoleranceThyroxineAdultFemaleHumansLactoseMalabsorption SyndromesMaleMiddle AgedThyrotropinLactoseThyrotropinThyroxineautoimmune thyroiditishypothyroidismlactose intoleranceliquid L-T4malabsorption

Identifiers

PMID38665263
PMCPMC11044000
OpenAlexW4394720017

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.