Evidence map›Paper›PMID 38665835›Full record

ArticleRSC medicinal chemistry2024

Design, synthesis, and evaluation of novel ferrostatin derivatives for the prevention of HG-induced VEC ferroptosis.

Xin-Xin Wang, Run-Jie Wang, Hua-Long Ji, Xiao-Yu Liu, Nai-Yu Zhang, Kai-Ming Wang, Kai Chen, Ping-Ping Liu, Ning Meng, Cheng-Shi Jiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Xin-Xin WangSchool of Biological Science and Technology, University of Jinan Jinan 250022 China mls_mengn@ujn.edu.cn bio_jiangcs@ujn.edu.cn.
Run-Jie WangKey Laboratory of Forest Plant Ecology, Ministry of Education, College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University Harbin 150040 China.
Hua-Long JiSchool of Biological Science and Technology, University of Jinan Jinan 250022 China mls_mengn@ujn.edu.cn bio_jiangcs@ujn.edu.cn.
Xiao-Yu LiuEvaluation Center of the New Drug, Shandong Academy of Pharmaceutical Sciences Jinan 250101 China chenkai@sdaps.cn.
Nai-Yu ZhangSchool of Biological Science and Technology, University of Jinan Jinan 250022 China mls_mengn@ujn.edu.cn bio_jiangcs@ujn.edu.cn.
Kai-Ming WangSchool of Biological Science and Technology, University of Jinan Jinan 250022 China mls_mengn@ujn.edu.cn bio_jiangcs@ujn.edu.cn.
Kai ChenEvaluation Center of the New Drug, Shandong Academy of Pharmaceutical Sciences Jinan 250101 China chenkai@sdaps.cn.
Ping-Ping LiuDepartment of Gynaecology and Obstetrics, 960th Hospital of PLA Jinan 250000 China 13065010512@163.com.
Ning MengSchool of Biological Science and Technology, University of Jinan Jinan 250022 China mls_mengn@ujn.edu.cn bio_jiangcs@ujn.edu.cn.
Cheng-Shi JiangSchool of Biological Science and Technology, University of Jinan Jinan 250022 China mls_mengn@ujn.edu.cn bio_jiangcs@ujn.edu.cn.ORCID https://orcid.org/0000-0002-2760-7596
University of Jinan · CNShandong Academy of Pharmaceutical Sciences · CN82th Hospital of Pla · CNNortheast Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a nonapoptotic, iron-catalyzed form of regulated cell death. It has been shown that high glucose (HG) could induce ferroptosis in vascular endothelial cells (VECs), consequently contributing to the development of various diseases. This study synthesized and evaluated a series of novel ferrostatin-1 (Fer-1) derivatives fused with a benzohydrazide moiety to prevent HG-induced VEC ferroptosis. Several promising compounds showed similar or improved inhibitory effects compared to positive control Fer-1. The most effective candidate 12 exhibited better protection against erastin-induced ferroptosis and high glucose-induced ferroptosis in VECs. Mechanistic studies revealed that compound 12 prevented mitochondrial damage, reduced intracellular ROS accumulation, upregulated the expression of GPX4, and decreased the amounts of ferrous ion, LPO and MDA in VECs. However, compound 12 still exhibited undesirable microsomal stability like Fer-1, suggesting the need for further optimization. Overall, the present findings highlight ferroptosis inhibitor 12 as a potential lead compound for treating ferroptosis-associated vascular diseases.

Identifiers

PMID38665835
PMCPMC11042167
OpenAlexW4392250753

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.