Evidence map›Paper›PMID 38667332›Full record

ArticleCells2024

AAV-Mediated Restoration of Dystrophin-Dp71 in the Brain of Dp71-Null Mice: Molecular, Cellular and Behavioral Outcomes.

Ophélie Vacca, Faouzi Zarrouki, Charlotte Izabelle, Mehdi Belmaati Cherkaoui, Alvaro Rendon, Deniz Dalkara, Cyrille Vaillend

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ophélie VaccaUniversité Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91400 Saclay, France.ORCID 0000-0001-9281-843X
Faouzi ZarroukiUniversité Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91400 Saclay, France.
Charlotte IzabelleUniversité Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91400 Saclay, France.ORCID 0000-0001-5723-3129
Mehdi Belmaati CherkaouiUniversité Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91400 Saclay, France.
Alvaro RendonDepartment of Therapeutics, Sorbonne University, Institut de la Vision, 75012 Paris, France.
Deniz DalkaraDepartment of Therapeutics, Sorbonne University, Institut de la Vision, 75012 Paris, France.
Cyrille VaillendUniversité Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91400 Saclay, France.ORCID 0000-0002-8783-8185
Centre National de la Recherche Scientifique · FRInstitut de la Vision · FR

Funding

Agence Nationale de la Recherche ANR-14-CE13-0037-01Association Monégasque contre les Myopathies (AMM, Monaco) N/ACentre National de la Recherche Scientifique N/ACoopération et Partenariat France-Amérique Latine - ECOS Nord M16SO1European Union 847826French Muscular Dystrophy Association 18944University of Paris-Saclay N/A
6 · The paper itself

Abstract

A deficiency in the shortest dystrophin-gene product, Dp71, is a pivotal aggravating factor for intellectual disabilities in Duchenne muscular dystrophy (DMD). Recent advances in preclinical research have achieved some success in compensating both muscle and brain dysfunctions associated with DMD, notably using exon skipping strategies. However, this has not been studied for distal mutations in the

Indexed as

BrainDependovirusDystrophinMembrane ProteinsMuscle ProteinsAnimalsAquaporin 4Behavior, AnimalCalcium-Binding ProteinsDisease Models, AnimalGenetic TherapyGenetic VectorsMaleMiceMice, Inbred C57BLMice, Knockoutapo-dystrophin 1Aquaporin 4Calcium-Binding ProteinsDmd protein, mouseDystrophinMembrane ProteinsMuscle Proteinssyntrophin alpha1AAVbehaviorbraincentral nervous systemdystrophin-Dp71gene therapyglia

Identifiers

PMID38667332
PMCPMC11049308
OpenAlexW4394998884

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.