Evidence map›Paper›PMID 38669115›Full record

ArticleAging2024

Mechanism of ameliorating cerebral ischemia/reperfusion injury by antioxidant inhibition of autophagy based on network pharmacology and experimental verification.

Yuantie Zheng, Zhicheng Huang, Yang Zhao, Lili Huang, Jun Wang, Heping Li, Xing Chen, Jingsong Wang, Jingwen Xie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Yuantie ZhengDepartment of Pharmacy, The Second Affiliated Hospital and Yuying Children’s Hospital of the Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhicheng HuangDepartment of Pharmacy, Ezhou Central Hospital, Ezhou, Hubei, China.
Yang ZhaoDepartment of Pharmacy, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Lili HuangDepartment of Pharmacy, Lihuili Hospital Affiliated to Ningbo University, Ningbo, Zhejiang, China.
Jun WangDepartment of Pharmacy, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Heping LiDepartment of Pharmacy, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Xing ChenDepartment of Pharmacy, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Jingsong WangDepartment of Pharmacy, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Jingwen XieDepartment of Pharmacy, The Second Affiliated Hospital and Yuying Children’s Hospital of the Wenzhou Medical University, Wenzhou, Zhejiang, China.
Taiyuan Central Hospital · CNEzhou Central Hospital · CNNingbo Medical Center Lihuili Hospital · CNSecond Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia-reperfusion injury (CIRI) is one of the most difficult challenges in cerebrovascular disease research. It is primarily caused by excessive autophagy induced by oxidative stress. Previously, a novel compound X5 was found, and the excellent antioxidant activity of it was verified in this study. Moreover, network pharmacological analysis suggested that compound X5 was closely associated with autophagy and the mTOR pathway.

Indexed as

AntioxidantsAutophagyNetwork PharmacologyReperfusion InjurySirtuin 1TOR Serine-Threonine KinasesAnimalsBeclin-1Brain IschemiaDisease Models, AnimalHydrogen PeroxideInfarction, Middle Cerebral ArteryMaleOxidative StressRatsRats, Sprague-DawleyAntioxidantsBeclin-1Hydrogen PeroxidemTOR protein, ratSirt1 protein, ratSirtuin 1TOR Serine-Threonine Kinasesautophagynetwork pharmacologySIRT1stroke

Identifiers

PMID38669115
PMCPMC11087111
OpenAlexW4395480994

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.