ArticleProceedings of the National Academy of Sciences of the United States of America2024
Core planar cell polarity genes
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
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Who cites it
9 citing papers in PubMed, 7 citations in OpenAlex.
- Phosphorylated HPV‑16 E7 disrupts planar cell polarity in cervical cancer cells through vangl1 dysregulation.PLoS pathogens · 2026Article
- Advances in the etiology of congenital scoliosis: from morphology to spatiotemporal molecular mechanisms (2015-2025).EFORT open reviews · 2026Article
- Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Wnt11 mediates fibroblast-smooth muscle cell interaction to promote neurogenic bladder fibrosis in rats.Communications biology · 2026Article
- The role of genetics and molecular mechanisms in early onset scoliosis.Journal of clinical orthopaedics and trauma · 2026Review
- VANGL1 links angiogenesis-stemness programs and tumor microenvironment remodeling: a pan-cancer, multi-omics study with translational validation.Frontiers in oncology · 2026Article
- Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1.Nature communications · 2025Article
- GREGoR: Accelerating Genomics for Rare Diseases.ArXiv · 2024Article
- Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis.Development (Cambridge, England) · 2024Article
Corrections and comments
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Authors and funding
41 authors at 10 institutions in 4 countries.
Xin Feng *School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Yongyu Ye *Department of Orthopedic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Jianan Zhang *School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Yuanqiang ZhangDepartment of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Sen ZhaoDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Judith C W MakDepartment of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0002-8234-1313
Nao OtomoDepartment of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Zhengye ZhaoDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Yuchen NiuBeijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing 100730, China.
Yoshiro YonezawaDepartment of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Guozhuang LiDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Mao LinDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.ORCID 0000-0001-6899-8370
Xiaoxin LiBeijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing 100730, China.
Prudence Wing Hang CheungDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Kexin XuDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Kazuki TakedaDepartment of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Shengru WangDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Junjie XieSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Toshiaki KotaniDepartment of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Vanessa N T ChoiSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
You-Qiang SongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0001-9407-2256
Yang YangDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Keith Dip Kei LukDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0003-0547-8890
Kin Shing LeeCenter for Comparative Medicine Research, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Ziquan LiDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Pik Shan LiCenter for Comparative Medicine Research, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Connie Y H LeungCenter for Comparative Medicine Research, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0003-1102-4684
Xiaochen LinSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Xiaolu WangSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Guixing QiuDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
DISCO (Deciphering disorders Involving Scoliosis and COmorbidities) study group
Kota WatanabeDepartment of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Japanese Early Onset Scoliosis Research Group
Zhihong WuDepartment of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Jennifer E PoseyDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston 77030, TX.
Shiro IkegawaLaboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo 108-8639, Japan.
James R LupskiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston 77030, TX.ORCID 0000-0001-9907-9246
Jason Pui Yin CheungDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0002-7052-0875
Terry Jianguo ZhangDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Bo GaoSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0002-8684-5199
Nan WuDepartment of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, all at Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.ORCID 0000-0002-9429-2889
Chinese Academy of Medical Sciences & Peking Union Medical College · CNChinese University of Hong Kong · HKKeio University · JPUniversity of Hong Kong · HKBaylor College of Medicine · USFirst Affiliated Hospital Zhejiang University · CNGuangdong Academy of Medical Sciences · CNQilu Hospital of Shandong University · CNRIKEN Center for Integrative Medical Sciences · JPUniversity of Hong Kong - Shenzhen Hospital · CN
Funding
Baylor-Johns Hopkins Center for Mendelian GeneticsUM1HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2016 to 2020
$14.5MFrequency of variants of unknown significance by ancestry groups in the All of Us Research Program cohortU01HG011758 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI RICHARD A GIBBS, JAMES R. LUPSKI · 2021 to 2026
$13.8MNHGRI NIH HHS U01 HG011758NHGRI NIH HHS UM1 HG006542
Abstract
Congenital scoliosis (CS), affecting approximately 0.5 to 1 in 1,000 live births, is commonly caused by congenital vertebral malformations (CVMs) arising from aberrant somitogenesis or somite differentiation. While Wnt/ß-catenin signaling has been implicated in somite development, the function of Wnt/planar cell polarity (Wnt/PCP) signaling in this process remains unclear. Here, we investigated the role of
Indexed as
Carrier ProteinsCell PolarityMembrane ProteinsSpineZebrafishAnimalsFemaleGenetic Predisposition to DiseaseHumansIntracellular Signaling Peptides and ProteinsMiceNerve Tissue ProteinsScoliosisWnt Signaling PathwayZebrafish ProteinsCarrier ProteinsIntracellular Signaling Peptides and ProteinsLtap protein, mouseMembrane ProteinsNerve Tissue ProteinsVANGL1 protein, humanVangl1 protein, mouseVANGL2 protein, humanvangl2 protein, zebrafishZebrafish Proteinscongenital scoliosiscongenital vertebral malformationplanar cell polarity (PCP)somiteVANGL1/2
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.