Evidence map›Paper›PMID 38670102›Full record

ArticleDevelopmental cell2024

The Zn

Xiaoran Guo, Morgan Mutch, Alba Yurani Torres, Maddalena Nano, Nishi Rauth, Jacob Harwood, Drew McDonald, Zijing Chen, Craig Montell, Wei Dai and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Metal Ions Within the Neuro-Immune-Tumor Axis.Journal of immunology research · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Xiaoran GuoMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Morgan MutchMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Alba Yurani TorresMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Maddalena NanoMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Nishi RauthMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Jacob HarwoodMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Drew McDonaldMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Zijing ChenMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Craig MontellMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA.
Wei DaiMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA; Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China. Electronic address: wei_dai@fudan.edu.cn.
Denise J MontellMolecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93110, USA. Electronic address: dmontell@ucsb.edu.
University of California, Santa Barbara · USFudan University · CN

Funding

Unconventional roles for opsinsR01EY008117 · NEI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MONTELL, CRAIG · 1989 to 2022
$8.2M
Making and breaking cell-cell contacts in developmentR01GM073164 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MONTELL, DENISE J. · 2005 to 2025
$6.2M
Opsins as a new class of evolutionarily conserved taste receptors: Diversity Supplement for Pre-Doctoral TrainingR01DC016278 · NIDCD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI CRAIG MONTELL · 2017 to 2026
$4.7M
Mechanisms of visual transduction and light-driven behaviors in Aedes aegyptiR01AI169386 · NIAID · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI CRAIG MONTELL · 2022 to 2026
$2.4M
Mechanisms of stem cell preservation and lifespan extension in DrosophilaR01AG063907 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MONTELL, DENISE J. · 2019 to 2023
$1.6M
NEI NIH HHS R01 EY008117NIAID NIH HHS R01 AI169386NIA NIH HHS R01 AG063907NIDCD NIH HHS R01 DC016278NIGMS NIH HHS R01 GM073164NIH HHS R01 AG36907
6 · The paper itself

Abstract

Proteotoxic stress drives numerous degenerative diseases. Cells initially adapt to misfolded proteins by activating the unfolded protein response (UPR), including endoplasmic-reticulum-associated protein degradation (ERAD). However, persistent stress triggers apoptosis. Enhancing ERAD is a promising therapeutic approach for protein misfolding diseases. The ER-localized Zn

Indexed as

Cation Transport ProteinsDrosophila ProteinsEndoplasmic ReticulumEndoplasmic Reticulum-Associated DegradationZincAnimalsCell MovementDrosophilaDrosophila melanogasterHumansProteasome Endopeptidase ComplexProteolysisUbiquitinationUnfolded Protein ResponseCation Transport ProteinsDrosophila ProteinsProteasome Endopeptidase ComplexSLC39A7 protein, humanZincapoptosisborder cell migrationDrosophilaERADER stressintegrated stress responseneurodegenerationproteasomeretinitis pigmentosazinc transport

Identifiers

PMID38670102
PMCPMC11233247
OpenAlexW4395451063

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.