Evidence map›Paper›PMID 38672065›Full record

ArticleBiomedicines2024

Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders.

Sara Passerini, Giulia Babini, Elisabetta Merenda, Raffaella Carletti, Daniela Scribano, Luigi Rosa, Antonietta Lucia Conte, Ugo Moens, Livia Ottolenghi, Umberto Romeo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Sara PasseriniDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-0678-5537
Giulia BabiniDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.
Elisabetta MerendaDepartment of Radiological, Oncological and Pathological Science, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0002-7231-2295
Raffaella CarlettiDepartment of Radiological, Oncological and Pathological Science, "Sapienza" University of Rome, 00161 Rome, Italy.
Daniela ScribanoDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2901-265X
Luigi RosaLaboratory of Virology, National Institute for Infectious Diseases "Spallanzani", 00149 Rome, Italy.ORCID 0000-0002-1252-6080
Antonietta Lucia ConteDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.
Ugo MoensDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø, UiT-The Arctic University of Norway, 9037 Tromsø, Norway.
Livia OttolenghiDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0001-7390-4316
Umberto RomeoDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0003-2439-2187
Maria Pia ConteDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0753-6003
Cira Rosaria Tiziana Di GioiaDepartment of Radiological, Oncological and Pathological Science, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-4696-0560
Valeria PietropaoloDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5723-8886
Sapienza University of Rome · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITUiT The Arctic University of Norway · NO

Funding

Ministry of Education, Universities and Research RM11916B1DFD19A1Ministry of Education, Universities and Research RP12017260562B5E
6 · The paper itself

Abstract

Despite recent advances in prevention, detection and treatment, oral squamous cell carcinoma (OSCC) remains a global health concern, strongly associated with environmental and lifestyle risk factors and infection with oncogenic viruses. Merkel Cell Polyomavirus (MCPyV), well known to be the causative agent of Merkel Cell Carcinoma (MCC) has been found in OSCC, suggesting its potential role as a co-factor in the development of oral cavity cancers. To improve our understanding about MCPyV in oral cavities, the detection and analysis of MCPyV DNA, transcripts and miRNA were performed on OSCCs and oral potentially malignant disorders (OPMDs). In addition, the cellular miR-375, known to be deregulated in tumors, was examined. MCPyV DNA was found in 3 out of 11 OSCC and 4 out of 12 OPMD samples, with a viral mean value of 1.49 × 10

Indexed as

LTAgMerkel Cell PolyomavirusmiRNAsoral canceroral diseasesVP1

Identifiers

PMID38672065
PMCPMC11047982
OpenAlexW4393094437

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.