Evidence map›Paper›PMID 38672087›Full record

ArticleBiomedicines2024

Potential Role of Selected miRNAs in the Pathogenesis of Autoimmune Thyroid Diseases in Children and Adolescents.

Beata Sawicka, Anetta Sulewska, Agnieszka Kulczyńska-Przybik, Filip Bossowski, Maciej Dulewicz, Hanna Borysewicz-Sańczyk, Barbara Mroczko, Jacek Nikliński, Artur Bossowski

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Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Beata SawickaDepartment of Pediatrics, Endocrinology, Diabetology, with Cardiology Divisions, Medical University of Bialystok, 15-089 Bialystok, Poland.
Anetta SulewskaDepartment of Clinical Molecular Biology, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0001-7070-8491
Agnieszka Kulczyńska-PrzybikDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland.
Filip BossowskiDepartment of Pediatrics, Endocrinology, Diabetology, with Cardiology Divisions, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0002-0229-4597
Maciej DulewiczDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0002-7149-017X
Hanna Borysewicz-SańczykDepartment of Pediatrics, Endocrinology, Diabetology, with Cardiology Divisions, Medical University of Bialystok, 15-089 Bialystok, Poland.
Barbara MroczkoDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0002-4075-8479
Jacek NiklińskiDepartment of Clinical Molecular Biology, Medical University of Bialystok, 15-089 Bialystok, Poland.
Artur BossowskiDepartment of Pediatrics, Endocrinology, Diabetology, with Cardiology Divisions, Medical University of Bialystok, 15-089 Bialystok, Poland.ORCID 0000-0002-6316-5342

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany epigenetic factors, including microRNAs, are involved in the process of changing gene expressions. Small non-coding RNA molecules, called miRNAs, are responsible for regulating gene translation by silencing or degrading target mRNAs. It is acknowledged that for many diseases, they may be novel diagnostic and prognostic biomarkers. Patients with autoimmune thyroid diseases are more likely to develop nodules in the thyroid tissue, and Hashimoto's thyroiditis and Graves' disease predispose patients to thyroid cancer. We evaluated the concentrations of microRNA molecules (miR-15a-5p, miR-126-3p, miR-142-5p, miR-21-5p, miR-150-5p) in the blood of children with thyroid disorders. In addition, we wished to identify molecules whose change in concentration predisposes to the development of thyroid cancer.

aimThe aim of this study is to evaluate selected epigenetic elements by analyzing the levels of miR-15a-5p, miR-126-3p, miR-142-5p, miR-150-5p and miR-21-5p in the blood of pediatric patients with Graves' disease ( MATERIALS AND

methodsThe study consists of groups of children and adolescents aged 10-18 years with autoimmune thyroid disease, with thyroid nodular disease compared to a control group. The miR-15a-5p, miR-126-3p, miR-142-5p, miR-21-5p and miR-150-5p molecules were determined through an immunoenzymatic assay using BioVendor reagents.

resultsThere is a statistically significant decrease in the expression of the miR-15a-5p in children with Graves' disease (21.61 vs. 50.22 amol/μL,

conclusions1. The overexpression of the miR-142-5p molecule occurs in children and adolescents with thyroid diseases. 2. Decreased blood levels of miR-15a-5p predispose patients to the formation of focal lesions in the thyroid gland. 3. Identifying a lower expression of the miR-126-3p molecule in the blood of children with GD requires careful follow-up for the development of focal lesions in the thyroid gland and evaluation for their potential malignancy.

Indexed as

Graves’ diseaseHashimoto’s thyroiditismiRNAthyroid nodular disease

Identifiers

PMID38672087
PMCPMC11047951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.