ReviewLife (Basel, Switzerland)2024
Retinal Structural and Vascular Changes in Patients with Coronary Artery Disease: A Systematic Review and Meta-Analysis.
Review in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 12 citations in OpenAlex.
- Initiating Events of Retinopathy in Spontaneously Hypertensive Rats: Microvascular Rarefaction and Functional Deficits.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Optical coherence tomography enables optical biopsy of endometrial tissue for early cancer detection.Npj imaging · 2026Article
- The value of retinal microvascular features in predicting risk stratification and long-term prognosis of patients with acute coronary syndrome.BMC ophthalmology · 2026Article
- Ophthalmological Microvascular Changes in ANOCA/INOCA Disease and Ophthalmological Methods to Detect Them-A Systematic Review.Journal of clinical medicine · 2026Review
- A deep-learning system for the assessment of coronary heart disease risk via scleral photographs.Scientific reports · 2025Article
- Retinal microvascular changes in pediatric patients with thromboembolism: an optical coherence tomography angiography study.Irish journal of medical science · 2025Article
- Retinal and Choroidal Alterations in Heart Failure: A Systematic Review and Meta-analysis of OCT and OCT-A Findings with Emphasis on HFrEF.Ophthalmology and therapy · 2025Review
- Disease Diagnosis Using Retinal Vasculature: Insights from Flammer Syndrome and AI.Brain sciences · 2025Review
- Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease.Investigative ophthalmology & visual science · 2025Article
- Interdisciplinarity in Cardiovascular Diseases-A Necessity Alongside the Heart Team.Life (Basel, Switzerland) · 2025Article
- Causal Effects Between Retinal Characteristics and Cardiovascular Diseases: Insights from Genetic Correlation, Mendelian Randomization, and Cross-Sectional Study.Global heart · 2025Article
- Ocular Biometry Profile and Its Associations with Systemic and Demographic Factors in Thai Cataract Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- SS-OCTA assessment of fundus microvascular changes and their correlation with coronary lesion severity in severe coronary heart disease.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRetinal microvascular anomalies have been identified in patients with cardiovascular conditions such as arterial hypertension, diabetes mellitus, and carotid artery disease. We conducted a systematic review and meta-analysis (PROSPERO registration number CRD42024506589) to explore the potential of retinal vasculature as a biomarker for diagnosis and monitoring of patients with coronary artery disease (CAD) through optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).
methodsWe systematically examined original articles in the Pubmed, Embase, and Web of Science databases from their inception up to November 2023, comparing retinal microvascular features between patients with CAD and control groups. Studies were included if they reported sample mean with standard deviation or median with range and/or interquartile range (which were computed into mean and standard deviation). Review Manager 5.4 (The Cochrane Collaboration, 2020) software was used to calculate the pooled effect size with weighted mean difference and 95% confidence intervals (CI) by random-effects inverse variance method.
resultsEleven studies meeting the inclusion criteria were incorporated into the meta-analysis. The findings indicated a significant decrease in the retinal nerve fiber layer (WMD -3.11 [-6.06, -0.16]), subfoveal choroid (WMD -58.79 [-64.65, -52.93]), and overall retinal thickness (WMD -4.61 [-7.05, -2.17]) among patients with CAD compared to controls (
conclusionThe current meta-analysis suggests that retinal vascularization could function as a noninvasive biomarker, providing additional insights beyond standard routine examinations for assessing dysfunction in coronary arteries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.