Evidence map›Paper›PMID 38673940›Full record

ArticleInternational journal of molecular sciences2024

Serum Levels of miR-122-5p and miR-125a-5p Predict Hepatotoxicity Occurrence in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation.

Damian Mikulski, Kacper Kościelny, Izabela Dróżdż, Grzegorz Mirocha, Mateusz Nowicki, Małgorzata Misiewicz, Ewelina Perdas, Piotr Strzałka, Agnieszka Wierzbowska, Wojciech Fendler

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Damian MikulskiDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-2806-2583
Kacper KościelnyDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-2879-7985
Izabela DróżdżDepartment of Clinical Genetics, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0003-1956-5063
Grzegorz MirochaDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0009-0006-4621-6247
Mateusz NowickiDepartment of Hematology, Medical University of Lodz, 92-215 Lodz, Poland.
Małgorzata MisiewiczDepartment of Hematology, Medical University of Lodz, 92-215 Lodz, Poland.
Ewelina PerdasDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-2321-2976
Piotr StrzałkaDepartment of Hematology, Medical University of Lodz, 92-215 Lodz, Poland.
Agnieszka WierzbowskaDepartment of Hematology, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0001-7909-457X
Wojciech FendlerDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland.
Medical University of Lodz · PLCopernicus Memorial Hospital · PL

Funding

National Science Center 2019/33/B/NZ5/00536National Science Center 2022/45/N/NZ6/02904
6 · The paper itself

Abstract

Hepatic complications are an acknowledged cause of mortality and morbidity among patients undergoing hematopoietic stem cell transplantation. In this study, we aimed to evaluate the potential role in the prediction of liver injury of five selected microRNAs (miRNAs)-miR-122-5p, miR-122-3p, miR-15b-5p, miR-99b-5p, and miR-125a-5p-in the setting of autologous hematopoietic stem cell transplantation (ASCT). A total of 66 patients were included in the study: 50 patients (75.8%) with multiple myeloma (MM) and 16 (24.2%) with lymphoma. Blood samples were collected after the administration of the conditioning regimen, on the day of transplant (day 0). The expression levels of selected miRNAs were quantified by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) using the miRCURY LNA miRNA Custom PCR Panels (QIAGEN). In a multivariate logistic regression analysis adjusted for age, sex, and the administered conditioning regimen, two miRNAs, hsa-miR-122-5p (odds ratio, OR 2.10, 95% confidence interval, CI: 1.29-3.42,

Indexed as

Hematopoietic Stem Cell TransplantationMicroRNAsTransplantation, AutologousAdultAgedBiomarkersFemaleHumansLymphomaMaleMiddle AgedMultiple MyelomaROC CurveBiomarkersMicroRNAsMIRN122 microRNA, humanMIRN125 microRNA, humanASCThematopoietic stem cell transplanthepatotoxicityliver injurymiR-122-5pmiR-125a-5p

Identifiers

PMID38673940
PMCPMC11050045
OpenAlexW4394821896

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.