Evidence map›Paper›PMID 38673967›Full record

ArticleInternational journal of molecular sciences2024

The Antitumoral Effect In Ovo of a New Inclusion Complex from Dimethoxycurcumin with Magnesium and Beta-Cyclodextrin.

Marco A Obregón-Mendoza, William Meza-Morales, Karla Daniela Rodríguez-Hernández, M Mirian Estévez-Carmona, Leidys L Pérez-González, Rosario Tavera-Hernández, María Teresa Ramírez-Apan, David Barrera-Hernández, Mitzi García-Olivares, Brian Monroy-Torres and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Polymorphs of Diacetylcurcumin (DAC).Molecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marco A Obregón-MendozaInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0001-7932-2958
William Meza-MoralesInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0002-2759-4334
Karla Daniela Rodríguez-HernándezInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0003-0639-2327
M Mirian Estévez-CarmonaDepartamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, M. Wilfrido Massieu SN, U. A. Zacatenco, Mexico City 07738, Mexico.ORCID 0000-0001-9945-8545
Leidys L Pérez-GonzálezInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Rosario Tavera-HernándezInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0001-5501-2496
María Teresa Ramírez-ApanInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
David Barrera-HernándezDepartamento de Biología de la Reproducción "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.ORCID 0000-0003-2692-8213
Mitzi García-OlivaresDepartamento de Biología de la Reproducción "Dr. Carlos Gual Castro", Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
Brian Monroy-TorresInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0002-3409-504X
Antonio Nieto-CamachoInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0002-0900-6017
María Isabel ChávezInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Rubén Sánchez-ObregónInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Raúl G EnríquezInstituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías 307152 PRONACESUNAM DGAPA PAPIIT IT200720
6 · The paper itself

Abstract

Breast cancer is one of the leading causes of death in the female population because of the resistance of cancer cells to many anticancer drugs used. Curcumin has cytotoxic activities against breast cancer cells, although it has limited use due to its poor bioavailability and rapid metabolic elimination. The synthesis of metal complexes of curcumin and curcuminoids is a relevant topic in the search for more active and selective derivatives of these molecular scaffolds. However, solubility and bioavailability are concomitant disadvantages of these types of molecules. To overcome such drawbacks, the preparation of inclusion complexes offers a chemical and pharmacologically safe option for improving the aqueous solubility of organic molecules. Herein, we describe the preparation of the inclusion complex of dimethoxycurcumin magnesium complex (DiMeOC-Mg, (

Indexed as

Antineoplastic Agentsbeta-CyclodextrinsCurcuminMagnesiumAnimalsApoptosisBreast NeoplasmsCell Line, TumorCell MovementChick EmbryoCoordination ComplexesFemaleHumansMatrix Metalloproteinase 9SolubilitySTAT3 Transcription FactorAntineoplastic Agentsbeta-CyclodextrinsbetadexCoordination ComplexesCurcumindimethoxycurcuminMagnesiumMatrix Metalloproteinase 9STAT3 Transcription Factor3,4-dimethoxycurcuminantitumoral activitybeta-cyclodextrin complexesbreast cancercurcuminoidshomoleptic complexesinclusion complexes

Identifiers

PMID38673967
PMCPMC11050057

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.