Evidence map›Paper›PMID 38674332›Full record

ArticleGenes2024

The Involvement of the microRNAs miR-466c and miR-340 in the Palmitate-Mediated Dysregulation of Gonadotropin-Releasing Hormone Gene Expression.

Vanessa Nkechika, Ningtong Zhang, Denise D Belsham

Open access · goldAbstract read
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vanessa NkechikaDepartment of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.ORCID 0009-0005-2454-0372
Ningtong ZhangDepartment of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Denise D BelshamDepartment of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-7065-8591
University of Toronto · CA

Funding

CIHR MOP-133676
6 · The paper itself

Abstract

Diets high in saturated fatty acids are associated with obesity and infertility. Palmitate, the most prevalent circulating saturated fatty acid, is sensed by hypothalamic neurons, contributing to homeostatic dysregulation. Notably, palmitate elevates the mRNA levels of gonadotropin-releasing hormone (

Indexed as

Gene Expression RegulationGonadotropin-Releasing HormoneMicroRNAsPalmitatesAnimalsCCAAT-Enhancer-Binding Protein-betaGATA4 Transcription FactorHypothalamusMiceNeuronsCCAAT-Enhancer-Binding Protein-betaGata4 protein, mouseGATA4 Transcription FactorGonadotropin-Releasing HormoneMicroRNAsMirn466 microRNA, mousePalmitatesGnRHhypothalamusmicroRNAobesitypalmitatetranscription factors

Identifiers

PMID38674332
PMCPMC11048885
OpenAlexW4393149823

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.