Evidence map›Paper›PMID 38674441›Full record

ArticleGenes2024

Assessment of the Effect of Leonurine Hydrochloride in a Mouse Model of PCOS by Gene Expression Profiling.

Mengmeng Wang, Li Yang, Guojie Sun, Yongbin Shao, Yuran Liu, Huiying Yang, Yan Wang, Mengyuan Zhang, Yunxia Shang, Xinli Gu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mengmeng WangCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Li YangCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830052, China.
Guojie SunCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Yongbin ShaoCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Yuran LiuCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Huiying YangCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Yan WangCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Mengyuan ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Yunxia ShangCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Xinli GuCollege of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Shihezi University · CNXinjiang Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is an endocrine disease commonly associated with metabolic disorders in females. Leonurine hydrochloride (Leo) plays an important role in regulating immunity, tumours, uterine smooth muscle, and ovarian function. However, the effect of Leo on PCOS has not been reported. Here, we used dehydroepiandrosterone to establish a mouse model of PCOS, and some mice were then treated with Leo by gavage. We found that Leo could improve the irregular oestros cycle of PCOS mice, reverse the significantly greater serum testosterone (T) and luteinising hormone (LH) levels, significantly reduce the follicle-stimulating hormone (FSH) level, and significantly increase the LH/FSH ratio of PCOS mice. Leo could also change the phenomenon of ovaries in PCOS mice presented with cystic follicular multiplication and a lacking corpus luteum. Transcriptome analysis identified 177 differentially expressed genes related to follicular development between the model and Leo groups. Notably, the cAMP signalling pathway, neuroactive ligand-receptor interactions, the calcium signalling pathway, the ovarian steroidogenesis pathway, and the

Indexed as

Disease Models, AnimalGallic AcidPolycystic Ovary SyndromeAnimalsFemaleFollicle Stimulating HormoneGene Expression ProfilingLuteinizing HormoneMiceOvaryTestosteroneTranscriptomeFollicle Stimulating HormoneGallic AcidleonurineLuteinizing HormoneTestosteronedehydroepiandrosteroneleonurine hydrochloridepolycystic ovary syndrometranscriptome

Identifiers

PMID38674441
PMCPMC11050333
OpenAlexW4394918572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.