Evidence map›Paper›PMID 38674857›Full record

ArticleNutrients2024

Mendelian Randomization Analysis Identifies Inverse Causal Relationship between External Eating and Metabolic Phenotypes.

Yanina Timasheva, Zhanna Balkhiyarova, Diana Avzaletdinova, Tatyana Morugova, Gulnaz F Korytina, Arie Nouwen, Inga Prokopenko, Olga Kochetova

Abstract read
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In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanina TimashevaInstitute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, Ufa 450054, Russia.ORCID 0000-0002-9918-6962
Zhanna BalkhiyarovaSection of Statistical Multi-Omics, Department of Clinical & Experimental Medicine, School of Biosciences & Medicine, University of Surrey, Guildford GU2 7XH, UK.ORCID 0000-0003-3553-7126
Diana AvzaletdinovaDepartment of Medical Genetics and Fundamental Medicine, Bashkir State Medical University, Ufa 450008, Russia.
Tatyana MorugovaDepartment of Endocrinology, Bashkir State Medical University, Ufa 450008, Russia.
Gulnaz F KorytinaInstitute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, Ufa 450054, Russia.ORCID 0000-0002-1695-5173
Arie NouwenDepartment of Psychology, Middlesex University, London NW4 4BT, UK.
Inga ProkopenkoSection of Statistical Multi-Omics, Department of Clinical & Experimental Medicine, School of Biosciences & Medicine, University of Surrey, Guildford GU2 7XH, UK.ORCID 0000-0003-1624-7457
Olga KochetovaInstitute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, Ufa 450054, Russia.ORCID 0000-0002-2944-4428

Funding

The Ministry of Science and Higher Education of Russian Federation 075-15-2021-595
6 · The paper itself

Abstract

Disordered eating contributes to weight gain, obesity, and type 2 diabetes (T2D), but the precise mechanisms underlying the development of different eating patterns and connecting them to specific metabolic phenotypes remain unclear. We aimed to identify genetic variants linked to eating behaviour and investigate its causal relationships with metabolic traits using Mendelian randomization (MR). We tested associations between 30 genetic variants and eating patterns in individuals with T2D from the Volga-Ural region and investigated causal relationships between variants associated with eating patterns and various metabolic and anthropometric traits using data from the Volga-Ural population and large international consortia. We detected associations between

Indexed as

Diabetes Mellitus, Type 2Feeding BehaviorGhrelinMendelian Randomization AnalysisPhenotypeAdenylyl CyclasesAdultBody Mass IndexFemaleGenetic VariationGenome-Wide Association StudyGlycated HemoglobinHumansMaleMetabolic SyndromeMiddle Agedadenylate cyclase 3Adenylyl CyclasesCDKAL1 protein, humanGhrelinGHRL protein, humanGlycated HemoglobintRNA MethyltransferasesDEBQeating behaviourgenetic predictorsMendelian randomization

Identifiers

PMID38674857
PMCPMC11054043

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.