In Vivo Imaging of Acute Hindlimb Ischaemia in Rat Model: A Pre-Clinical PET Study.
Gergely Farkasinszky, Judit Szabó Péliné, Péter Károlyi, Szilvia Rácz, Noémi Dénes, Tamás Papp, József Király, Zsuzsanna Szabo, István Kertész, Gábor Mező and 3 more
Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
Phase I study of [European journal of nuclear medicine and molecular imaging · 2025
Article
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors at 2 institutions in 1 country.
Gergely FarkasinszkyDivision of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Judit Szabó PélinéDivision of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Péter KárolyiDoctoral School of Neuroscience, Faculty of Medicine, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary.
Szilvia RáczDivision of Radiology, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Noémi DénesDivision of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Tamás PappDoctoral School of Neuroscience, Faculty of Medicine, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary.ORCID 0000-0001-6437-0295
József KirályDepartment of Biopharmacy, Faculty of Pharmacy, University of Debrecen, H-4032 Debrecen, Hungary.
Zsuzsanna SzaboDepartment of Biopharmacy, Faculty of Pharmacy, University of Debrecen, H-4032 Debrecen, Hungary.
István KertészDivision of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-3822-9068
Gábor MezőInstitute of Chemistry, Faculty of Science, Eötvös Loránd University, H-1053 Budapest, Hungary.ORCID 0000-0002-7618-7954
Gabor HalmosDepartment of Biopharmacy, Faculty of Pharmacy, University of Debrecen, H-4032 Debrecen, Hungary.
Zita KépesDivision of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-2889-8521
György TrencsényiDivision of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0001-6456-6212
University of Debrecen · HUEötvös Loránd University · HU
Funding
European Union and the State of Hungary through the European Regional Development Fund GINOP-2.3.2-15-2016-00043New National Excellence Program Of The Ministry For Culture And Innovation From The Source Of The National Research, Development And Innovation Fund. ÚNKP-23-4-II , ÚNKP-23-4-I-DE-157Thematic Excellence Programme The Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund (TKP2021-EGA funding scheme) TKP2021-EGA-20 (Biotechnology)
6 · The paper itself
Abstract
backgroundTo better understand ischaemia-related molecular alterations, temporal changes in angiogenic Aminopeptidase N (APN/CD13) expression and glucose metabolism were assessed with PET using a rat model of peripheral arterial disease (PAD).
methodsThe mechanical occlusion of the base of the left hindlimb triggered using a tourniquet was applied to establish the ischaemia/reperfusion injury model in Fischer-344 rats. 2-[
resultsDue to a cellular adaptation to hypoxia, a gradual increase in [
conclusionsThe PET-based longitudinal assessment of angiogenesis-associated APN/CD13 expression and glucose metabolism during ischaemia may continue to broaden our knowledge on the pathophysiology of PAD.
Indexed as
2-[18F]FDG[68Ga]Ga-NOTA-c(NGR)aminopeptidase N (APN/CD13)angiogenesisischaemiaPeripheral Arterial Disease (PAD)positron emission tomography (PET)preclinical
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
In Vivo Imaging of Acute Hindlimb Ischaemia in Rat Model: A Pre-Clinical PET Study. · full record | Socratic